HomeResearchIntramural ResearchResearch Branches at NHGRI Genome Technology Branch

Genome Technology Branch

Investigators in the Genome Technology Branch (GTB) study the structure and function of genomes in disease and normal states. Over the years, GTB researchers have developed world-class expertise in a wide range of genomic techniques, including the mapping and sequencing of mammalian chromosomes, gene isolation, systematic mutagenesis, developmental genomics, and computational analysis of DNA and protein sequences. This work has been applied to the development, testing, and implementation of a range of innovative technologies for performing genome sequencing, screening, and analysis. GTB investigators are actively studying the genetic causes of rare disorders, such as hereditary deafness, progeria, and peripheral neuropathies. They also are studying genetic contributions to more common conditions, such as type 2 diabetes and neural tube defects, and are investigating how particular genes may influence normal health and even longevity.

GTB houses core units and centers that provide genomic services to NHGRI and the broader National Institutes of Health (NIH) community. Many intramural scientists at other NIH Institutes have tapped into GTB's expertise in large-scale DNA sequencing and its applications, and others have benefited from GTB's developments in computational genomics. GTB investigators are involved in a number of joint ventures with other NIH Institutes to develop resources for the genomic research community, including numerous genome analysis tools and resources that are freely available on the NHGRI website.

Senior Investigators

Eric D. Green, M.D., Ph.D.
Scientific Director, NHGRI
Senior Investigator and Chief, Genome Technology Branch
Director, NIH Intramural Sequencing Center (NISC)
Head, Physical Mapping Section

Lawrence C. Brody, Ph.D.
Senior Investigator, Genome Technology Branch
Head, Molecular Pathogenesis Section

Elizabeth G. Nabel, M.D.
Director, National Heart, Lung and Blood Institute (NHLBI)
Senior Investigator, Genome Technology Branch
Head, Vascular Biology and Genomics Section

Investigators

Shawn Burgess, Ph.D.
Investigator, Genome Technology Branch
Head, Developmental Genomics Section

Laura L. Elnitski, Ph.D.
Investigator, Genome Technology Branch
Head, Genomic Functional Analysis Section

Elliott Margulies, Ph.D.
Investigator, Genome Technology Branch
Head, Genome Informatics Section

Associate Investigators

Christopher P. Austin, M.D.
Associate Investigator, Genome Technology Branch
Director, NIH Chemical Genomics Center
Senior Advisor to the Director for Translational Research, Office of the Director

Andy Baxevanis, Ph.D.
Deputy Scientific Director, NHGRI
Associate Investigator, Genome Technology Branch
Head, Computational Genomics Unit
Director, Bioinformatics and Scientific Programming Core
Acting Director, Intramural Training Office

Robert W. Blakesley, Ph.D.
Associate Investigator, Genome Technology Branch
Director, Sequencing Group, NIH Intramural Sequencing Center (NISC)

Gerard Bouffard, Ph.D.
Associate Investigator, Genome Technology Branch
Director, Bioinformatics Group, NIH Intramural Sequencing Center (NISC)

Settara C. Chandrasekharappa, Ph.D.
Associate Investigator, Genome Technology Branch
Head, Gene Identification Unit

Jim Inglese, Ph.D.
Associate Investigator, Genome Technology Branch
Director, Biomolecular Screening and Profiling Division, NIH Chemical Genomics Center

James C. Mullikin, Ph.D.
Associate Investigator, Genome Technology Branch
Head, Comparative Genomics Unit

Tyra Wolfsberg, Ph.D.
Associate Investigator, Genome Technology Branch
Associate Director, Bioinformatics and Scientific Programming Core

Research Project Web Sites

Breast Cancer Information Core

Human Chromosome 7 Mapping and Sequencing

WebBLAST

Histone Sequence Database

Homeodomain Resource

Top of page

Last Updated: August 3, 2008