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Federal Register: NTP Meeting - Review of Draft Technical Reports
[Federal Register: November 18,1996 (Volume 61, Number 223)]
[Notices]
[Page 58698-57588]
[Notices]
[Page 58698-57588]
DEPARTMENT OF HEALTH AND HUMAN SERVICES
National Institute of Environmental Health Sciences; National Toxicology Program (NTP) Board of Scientific Counselors' Meeting;Review of Draft NTP Technical Reports
Pursuant to Public Law 92-463, notice is hereby given of the next meeting of the NTP Board of Scientific Counselors' Technical Reports Review Subcommittee on December 11 and 12, 1996, in the Conference Center, Building 101, South Campus, National Institute of Environmental Health Sciences (NIEHS), 111 Alexander Drive, Research Triangle Park, North Carolina. The meeting will begin at 8:30 a.m. both days and is open to the public. The agenda topic is the peer review of draft Technical Reports of long-term toxicology and carcinogenesis studies from the National Toxicology Program.
Tentatively scheduled to be peer reviewed on December 11-12 are draft Technical Reports of 10 two-year studies, listed alphabetically, along with supporting information in the attached table. All studies were done using Fischer 344 rats and B6C3F1 mice. The order of review is given in the far right column of the table. Copies of the draft Reports may be obtained, as available, from: Central Data Management, MD E1-02, P.O. Box 12233, Research Triangle Park, NC 27709 (919/541-3419) or send e-mail to CDM@niehs.nih.gov.
Persons wanting to make a formal presentation regarding a particular Technical Report must notify the Executive Secretary by telephone, by FAX, or by mail no later than December 6, 1996, and provide a written copy in advance of the meeting so copies can be made and distributed to all Subcommittee members and staff and made available at the meeting for attendees. Written statements should supplement and may expand on the oral presentation. Oral presentations should be limited to no more than five minutes.
The program would welcome receiving toxicology and carcinogenesis information from completed, ongoing, or planned studies by others, as well as current production data, human exposure information, and use patterns for any of the chemicals listed in this announcement. Please contact Central Data Management at the address given above, and they will relay the information to the appropriate staff scientist.
The Executive Secretary, Dr. Larry G. Hart, P.O. Box 12233, Research Triangle Park, North Carolina 27709 (telephone 919/541-3971; FAX 919/541-0295) will furnish agenda and a roster of Subcommittee members prior to the meeting. Summary minutes subsequent to the meeting will be available upon request to Central Data Management.
Dated: November 11, 1996
______________________________________
Kenneth Olden, Ph. D.
Director, National Toxicology Program
Summary Data for Technical Reports Tentatively Scheduled for Review at the Meeting of the Board of Scientific Counselor's Technical Reports Review Subcommittee December 11-12, 1996
| CHEMICAL CAS NUMBER |
TECHNICAL REPORT NUMBER |
PRIMARY USES | ROUTE/ EXPOSURE LEVELS |
REVIEW ORDER |
|---|---|---|---|---|
| 3'-AZIDO-3'-DEOXYTHYMIDINE (AZT) 30516-87-1 and
INTERFERON AD + AZT
| TR-469 | Pyrimidine nucleoside analog with antiviral activity used in the treatment of AIDS (Merck 1989).
| (Gavage 5% Methylcellulose): Mice only: 0, 30, 60, OR 120 MG/KG; 50/SEX Subcutaneous Inj. + Gavage (.5% Methylcellulose): Dual routes with both compounds: AZT: 0, 30, 60, or 120 (gav) mg/kg; IFN: 500 OR 5000 units 3x/week | 2 |
| CHLOROPRENE 126-99-8 | TR-467 | Monomer for neoprene elastomers; industrial rubber products; component of laboratory adhesives in food packaging. | Inhalation (Air): Rats & Mice: 0, 12.8, 32.0, OR 80.0 PPM; 50/SEX/ SPECIES/GROUP | 4 |
| COBALT SULFATE HEPTAHYDRATE 10026-24-1 | TR-471 | Drying agent for varnishes and inks; component of electroplating solutions | Inhalation (Air): Rats & Mice: 0, 0.3, 1.0, OR 3.0 MG/M3; 50/SEX/ SPECIES/GROUP | 3 |
| ETHYLBENZENE 100-41-4 | TR-466 | Manufacture of synthetic rubber. Solvent. Fuel additive. Chemical intermediate. | Inhalation (Air) Rats & Mice: 0, 75, 250, 750 PPM (50/SEX/SPECIES/GROUP) | 6 |
| ISOBUTYRALDEHYDE 78-84-2 | TR-472 | Synthesis of pantothenic acid, cellulose esters, perfumes, flavors, and gasoline additives. Chemical intermediate. | Inhalation (Air): Rats & Mice: 0, 500, 1000, OR 2000 PPM (50/SEX/ SPECIES/GROUP) | 10 |
| OXAZEPAM 604-75-1 | TR-468 | Tranquilizer | Dosed-Feed (NIH-07): Rats only: 0, 625, 1250, 2500, 5000, OR 10000 PPM; 50/SEX/GROUP | 1 |
| POLYVINYL ALCOHOL 9002-89-5 | TR-474 | PVA film for intravaginal administration of spermicides. Textile warp sizing and finishing. adhesives. Pesticides. Pigment in TV picture tubes. | Intravaginal (Deionized Water): Mice only: 25% PVA, VEHICLE, UNTREATED; 100/GROUP | 8 |
| PRIMIDONE (PRIMACLONE) 125-33-7 | TR-476 | Prophylactic management of partial grand mal and psychomotor seizures that are refractory to other antiepileptic drugs. | Dosed-Feed (NIH-07 Mice: 0, 0.03, 0.06, OR 0.13% Rats: 0, 0.06, 0.13, OR 0.25% (50/SEX/SPECIES) | 9 |
| TETRAHYDROFURAN 109-99-9 | TR-475 | Reaction medium for grignard and metal hydride reactions. Packaging fabrication. Solvent for resins and plastics. Chemical intermediate. | Inhalation (Air): Rats & Mice: 0, 200, 600, OR 1800 PPM (50/SEX/ SPECIES/GROUP) | 7 |
| THEOPHYLLINE 58-55-9 | TR-473 | Diuretic, cardiac stimulant, smooth muscle relaxant, antiasthmatic, occurs naturally in tea (Merck 1989) | Gavage (Corn Oil): Rats: 0, 7.5, 25, OR 75 MG/KG; 50/GROUP Female Mice: 0, 7.5, 25, OR 75 MG/KG; 50/GROUP Male Mice: 0, 15, 50, OR 150 MG/KG; 50/GROUP | 5 |
[FR Doc. 96-29465 Filed 11-15-96; 8:45 am]
BILLING CODE 4140-01-M]
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