• To assess the percentage of patients who present with dysphagia who have EE by histologic criteria [ Time Frame: December 2010 ] [ Designated as safety issue: No ]
  

• To assess the demographics of the EE patients with dysphagia [ Time Frame: December 2010 ] [ Designated as safety issue: No ]
  
• To measure the frequency, severity, and time course of dysphagia in patients with EE [ Time Frame: December 2010 ] [ Designated as safety issue: No ]
  
• To assess percentage of EE patients with recurrent, versus acute dysphagia [ Time Frame: December 2010 ] [ Designated as safety issue: No ]
  

All patients presenting with dysphagia who do not already carry a previous diagnosis for their dysphagia will be asked to enroll. If patients have undergone previous work up for dysphagia such as manometry, 24-hour probe, or barium swallow they can still participate in this study. Informed consent will take place prior to enrollment. After patients present with dysphagia they will fill-out a questionnaire regarding their dysphagia symptoms. An EGD with biopsies will then be performed. Biopsies will be taken from 4 quadrants in the proximal and distal esophagus. The distal esophagus biopsies will be taken 5 cm proximal to the Z-line. Proximal biopsies will be taken anywhere proximal to 30 cm from the incisors.

All patients presenting with dysphagia will be eligibile for enrollment into the study.

Inclusion Criteria:

• Patients aged 18-90 presenting with dysphagia or food impaction
• Ability to undergo esophagogastroduodenoscopy and biopsies
• No significant cardiopulmonary disease, or other contraindication to EGD

Exclusion Criteria:

• Contradiction to EGD and/or biopsies such as Boehaave's syndrome, or history or bleeding disorder or elevated INR
• Inability to provide informed consent
• Esophageal varices