• To determine the maximum tolerated dose of TPI 287 administered every 21 days
  

• To determine the safety of TPI 287
  
• To determine the antitumor activity of TPI 287
  
• To determine the pharmacokinetic profile of TPI 287
  

The primary objective of this study is to determine the maximum tolerated dose of TPI 287 administered every 21 days for Phase II clinical trials.

Inclusion Criteria:

Patients must be/have:

• Histological evidence of malignancy
• Advanced solid tumors that have recurred or progressed following standard therapy
• Failed one prior therapy or have no standard therapy available
• Ambulatory with ECOG of 0-1 and estimated life expectancy of > 3 months
• If female, negative pregnancy test
• If of childbearing years, agree to use birth control
• If patient with prior radiation therapy for brain metastases, on steroids, must have been stable for 1 month

Exclusion Criteria:

Patients will be excluded if they are or have had:

• Prior radiation within 4 weeks
• Active medical condition or organ disease which may compromise safety or interfere with the study
• Clinically significant cardiac co-morbidities or pulmonary impairment
• Concomitant therapy needs
• Treated with any investigational drugs within 30 days
• Tumors involve major artery or vein
• Prior or concurrent central nervous system (CNS) disease
• Less than 4 weeks since major surgery
• Known to be positive for HIV, hepatitis B or C
• Concurrent use of aspirin
• Use of thrombolytic agents
• Uncontrolled hypertension
• Grade II-IV peripheral vascular disease
• Pregnant or lactating
• Prior allergic history to compounds of similar chemical composition
• Inpatients
• Grade II-IV peripheral neuropathy