The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.

Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.

Inclusion Criteria:

• Diagnosis of sickle cell disease

Exclusion Criteria:

• Pregnancy
• Claustrophobia
• Mass lesion (e.g., meningioma, cyst, or spinal block)
• Need for life support constant monitoring
• Any unstable condition that is likely to require resuscitation
• Presence of a pacemaker or other iron-containing magnetic substances in the body