Metabolic Effects of Cocaine - Full Text View

Metabolic Effects of Cocaine

This study has been completed.

Sponsors and Collaborators:	National Institute on Drug Abuse (NIDA) National Alliance for Research on Schizophrenia and Depression
Information provided by:	National Institute on Drug Abuse (NIDA)
ClinicalTrials.gov Identifier:	NCT00451230

Purpose

The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence

Condition	Intervention
Cocaine Dependence	Drug: cocaine Drug: hydrocortisone

ChemIDplus related topics:

Hydrocortisone Cortisol 21-phosphate Cortisol succinate Hydrocortamate Hydrocortisone 21-sodium succinate Hydrocortisone acetate Hydrocortisone cypionate Hydrocortisone hemisuccinate Proctofoam-HC Insulin 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))- Cocaine hydrochloride Epinephrine Epinephrine bitartrate Leptin

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Randomized, Double-Blind, Placebo Control, Single Group Assignment

Official Title:	Elucidating the Role of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Mechanisms Underlying Cocaine Dependence

Further study details as provided by National Institute on Drug Abuse (NIDA):

Estimated Enrollment:

Eligibility

Ages Eligible for Study:	21 Years to 49 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Individuals with DSM IV diagnosis of cocaine dependence, medically healthy

Exclusion Criteria:

Other than cocaine dependence DSM-IV axis I diagnosis

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00451230

Locations


United States, Massachusetts
	Massachusetts General Hospital
	Boston, Massachusetts, United States, 02116

Sponsors and Collaborators

National Institute on Drug Abuse (NIDA)

National Alliance for Research on Schizophrenia and Depression

Investigators


Principal Investigator:	Igor Elman	MGH

More Information

Publications indexed to this study:

Rott D, Langleben DD, Elman I. Cocaine decreases plasma insulin concentrations in non-diabetic subjects: a randomized double-blind study. Diabet Med. 2008 Apr;25(4):510-1. Epub 2008 Mar 13. No abstract available.

Study ID Numbers:	2000p 000323, DA#14410
First Received:	March 22, 2007
Last Updated:	March 22, 2007
ClinicalTrials.gov Identifier:	NCT00451230
Health Authority:	United States: Federal Government

Keywords provided by National Institute on Drug Abuse (NIDA):

craving, insulin, leptin

Study placed in the following topic categories:

Cocaine-Related Disorders

Dopamine

Hydrocortisone

Cortisol succinate

Mental Disorders

Substance-Related Disorders

Disorders of Environmental Origin

Hydrocortisone acetate

Epinephrine

Cocaine

Insulin

Additional relevant MeSH terms:

Anti-Inflammatory Agents

Dopamine Uptake Inhibitors

Neurotransmitter Agents

Neurotransmitter Uptake Inhibitors

Molecular Mechanisms of Pharmacological Action

Physiological Effects of Drugs

Anesthetics

Central Nervous System Depressants

Cardiovascular Agents

Pharmacologic Actions

Anesthetics, Local

Sensory System Agents

Therapeutic Uses

Vasoconstrictor Agents

Dopamine Agents

Peripheral Nervous System Agents

Central Nervous System Agents

ClinicalTrials.gov processed this record on September 19, 2008