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Sponsored by: |
New York University School of Medicine |
Information provided by: | National Cancer Institute (NCI) |
ClinicalTrials.gov Identifier: | NCT00003273 |
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells.
PURPOSE: Phase II trial to study the effectiveness of different regimens of combination chemotherapy followed by peripheral stem cell transplantation in treating children who have newly diagnosed brain tumor.
Condition | Intervention | Phase |
Brain and Central Nervous System Tumors Neuroblastoma Retinoblastoma Sarcoma |
Drug: carboplatin Drug: cisplatin Drug: cyclophosphamide Drug: etoposide Drug: filgrastim Drug: leucovorin calcium Drug: methotrexate Drug: temozolomide Drug: thiotepa Drug: vincristine sulfate Procedure: autologous bone marrow transplantation Procedure: peripheral blood stem cell transplantation Procedure: radiation therapy |
Phase II |
Genetics Home Reference related topics: | retinoblastoma |
MedlinePlus related topics: | Bone Marrow Transplantation Brain Cancer Cancer Childhood Brain Tumors Neuroblastoma Soft Tissue Sarcoma |
Study Type: | Interventional |
Study Design: | Treatment |
Official Title: | Dose Intensive Chemotherapy for Children Less Than Ten Years of Age Newly-Diagnosed With Malignant Brain Tumors: A Pilot Study of Two Alternative Intensive Induction Chemotherapy Regimens, Followed by Consolidation With Myeloablative Chemotherapy (Thiotepa, Etoposide and Carboplatin) and Autologous Stem Cell Rescue |
Ages Eligible for Study: | up to 10 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
Regimen A:
Posterior fossa medulloblastoma/primitive neuroectodermal tumor (PNET):
Supratentorial PNET, pineoblastoma, cerebral neuroblastoma, ependymoblastoma, medulloepithelioma, medullomyoblastoma:
Brainstem PNET:
Ependymoma or anaplastic ependymoma:
Supratentorial ependymoma:
Metastatic retinoblastoma:
Primary atypical teratoid/rhabdoid tumors of the CNS:
Choroid plexus carcinoma:
Regimen C:
Anaplastic astrocytoma, glioblastoma multiforme, anaplastic oligodendroglioma, anaplastic ganglioglioma, other anaplastic mixed gliomas:
Diffuse intrinsic pontine tumors:
The following diagnoses are not eligible:
PATIENT CHARACTERISTICS:
Age:
Performance status:
Life expectancy:
Hematopoietic:
Hepatic:
Renal:
PRIOR CONCURRENT THERAPY:
Biologic therapy:
Chemotherapy:
Endocrine therapy:
Radiotherapy:
Surgery:
United States, Hawaii | |||||
Cancer Research Center of Hawaii | |||||
Honolulu, Hawaii, United States, 96813 | |||||
United States, Maine | |||||
Maine Children's Cancer Program | |||||
Scarborough, Maine, United States, 04074-9308 | |||||
United States, Michigan | |||||
Spectrum Health and DeVos Children's Hospital | |||||
Grand Rapids, Michigan, United States, 49503 | |||||
United States, Nebraska | |||||
Children's Hospital of Omaha | |||||
Omaha, Nebraska, United States, 68114 | |||||
United States, New Jersey | |||||
Hackensack University Medical Center | |||||
Hackensack, New Jersey, United States, 07601 | |||||
United States, New York | |||||
Albert Einstein Clinical Cancer Center | |||||
Bronx, New York, United States, 10461 | |||||
Beth Israel Hospital North | |||||
New York, New York, United States, 10128 | |||||
Herbert Irving Comprehensive Cancer Center | |||||
New York, New York, United States, 10032 | |||||
Memorial Sloan-Kettering Cancer Center | |||||
New York, New York, United States, 10021 | |||||
NYU School of Medicine's Kaplan Comprehensive Cancer Center | |||||
New York, New York, United States, 10016 | |||||
State University of New York - Upstate Medical University | |||||
Syracuse, New York, United States, 13210 | |||||
State University of New York Health Sciences Center - Stony Brook | |||||
Stony Brook, New York, United States, 11790-7775 | |||||
Winthrop University Hospital | |||||
Mineola, New York, United States, 11501 | |||||
United States, Ohio | |||||
St. Vincent Mercy Medical Center | |||||
Toledo, Ohio, United States, 43608 | |||||
United States, Pennsylvania | |||||
Children's Hospital of Philadelphia | |||||
Philadelphia, Pennsylvania, United States, 19104 | |||||
Milton S. Hershey Medical Center | |||||
Hershey, Pennsylvania, United States, 17033-0850 | |||||
United States, Wisconsin | |||||
University of Wisconsin Comprehensive Cancer Center | |||||
Madison, Wisconsin, United States, 53792-6164 | |||||
Argentina | |||||
Children's Hospital | |||||
Buenos Aires, Argentina, 1425 | |||||
Canada, British Columbia | |||||
British Columbia Children's Hospital | |||||
Vancouver, British Columbia, Canada, V6H 3V4 |
New York University School of Medicine |
Study Chair: | Jonathan L. Finlay, MB, ChB | New York University School of Medicine |
Clinical trial summary from the National Cancer Institute's PDQ® database 
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Study ID Numbers: | CDR0000066174, NYU-P9712, NCI-V98-1400 |
First Received: | November 1, 1999 |
Last Updated: | August 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00003273 |
Health Authority: | United States: Federal Government |
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