| | Principal Investigators
| Barry B. Kaplan, Ph.D. |
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Dr.
Kaplan received his B.A. and M.S. degrees from Hofstra
University and his Ph.D. degree in cellular and developmental
biology from Cornell University. After completing postdoctoral
training in molecular neurobiology at the Andrus Gerontology
Center, University of Southern California, he joined the
faculty of the Department of Anatomy and Cell Biology
of the Cornell University Medical College. In 1983, he
moved to the Western Psychiatric Institute and Clinic,
University of Pittsburgh Medical Center, where he became
Director of the Molecular Neurobiology and Genetics Program.
In 1996, he relocated to the NIMH as Associate Director
of Fellowship Training in the Division of Intramural Research.
Dr. Kaplan’s laboratory is studying the subcellular
compartmentation of neuronal gene expression. |
| Research Interests |
| The
research program of the Neurobiology
Section focuses on the microcompartmentation of
neuronal gene expression. During the past few years, it
has become well established that the distal structural/functional
domains of large asymmetric neurons (i.e., distal dendrites,
axons, and nerve terminals) contain a heterogeneous population
of mRNAs, and that these mRNAs can serve as templates
for the de novo synthesis of protein. The goal of this
laboratory is to delineate the composition, cellular origin(s),
and function of these unique mRNA populations. Our studies
employ the squid giant axon and photoreceptor neuron as
model invertebrate motor and sensory systems, as well
as mammalian primary cell culture. It is hypothesized
that key elements of the cytomatrix, axon transport systems,
translation apparatus, and proteins involved in energy
metabolism are synthesized locally in the axon and presynaptic
nerve terminal, and that the local synthesis of protein
plays a key role in neuronal development, regeneration,
and plasticity. |
| Representative Selected Recent Publications: |
- Gioio AE, Lavina ZS, Jurkovicova D, Zhang H, Eyman M, Giuditta A, Kaplan BB:
Nerve terminals of squid photoreceptor neurons contain a heterogeneous population of mRNAs and translate a transfected reporter mRNA.
European Journal of Neuroscience, 20: 865-872, 2004. (View PDF)
- Kaplan BB, Lavina ZS, Gioio AE:
Subcellular compartmentation of neuronal protein synthesis: new insights into the biology of the neuron.
Annals of the NY Academy of Science,1018: 244-254, 2004. (View PDF)
- Wen H, Jurkovicova D, Pickel VM, Gioio AE, Kaplan BB:
Identification of a novel membrane-associated protein expressed in neurons of the squid and rodent nervous systems.
Neuroscience 114: 995-1004, 2002. (View PDF)
- Jimenez CR, Eyman M, Lavina ZS, Gioio A, Li KW, van der Schoros RC, Geraerts WP, Guiditta A, Kaplan BB, van Minnen J:
Protein synthesis in synaptosomes: a proteomics analysis.
Journal of Neurochemistry. 81: 735-744, 2002. (View PDF)
- Giuditta A, Kaplan BB, van Minnen J, Alveraez J, Koenig E:
Axonal and presynaptic protein synthesis: new insights into the biology of the neuron.
Trends in Neuroscience, 25: 400-404, 2002. (View PDF)
- Gioio AE, Eyman M, Zhang H, Lavina ZS, Giuditta A, Kaplan BB:
Local synthesis of nuclear-encoded mitochondrial proteins in the presynaptic nerve terminal.
Journal of Neuroscience Research, 64: 447-453, 2001.
(View PDF)
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Address:>
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| Phone: |
301-496-4183 |
| Email Dr. Kaplan |
| Fax: |
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| Lab Web Site:/td>
| No website available |
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