name Tor
status student
age 20s
Question - Since the mitochondria DNA is inherited entirely from
your mother, would my mitochondric DNA be the same as my great
grandmothers? How does this DNA change?
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Mutations in DNA occur at random. Usually there has to be some mutagen (ie.
radioactivity, UV rays) or a mistake in copying in just the right place to
cause a mutation. This doesn't necessarily happen at a regular rate. But we
can say that over a very long period of time, say a million years, or
100,000, or 10,000 years) a certain number of mutations are likely to have happened.
The longer period of time between two sequences of DNA that are being
compared, the greater likelihood there is that a mutation will have happened. So,
if you compare Neanderthal DNA to modern human DNA you see about 20
differences on average. Between any two unrelated modern humans there are about 6-8.
But mitochondrial DNA passes intact between mother and child. So your
grandmother should have gotten her mtDNA intact from her mother (your
great-grandmother). And so on. It is unlikely that in that small amount of time a
mutation will have occurred mathematically speaking. COULD it have happened?
Sure. But it isn't likely.
K VanHoeck
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Assuming no mutation, yes. I don't know what the mutation rate of mitochodrial DNA is,
but I would "guesstimate" that about one in 1,000 individuals would carry a newly
arising mutation when compared compared to their mother. You might try doing a search
on Google for "mitochondrial DNA mutation rate".
Ron Baker, Ph.D.
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Argonne National Laboratory, Division of Educational Programs, Harold Myron, Ph.D., Division Director.