Department of Health and Human Services -
Department of Health and Human Services - - A Service of the National Health Information Center, U.S. Department of Health and Human Services Home   |   About Us   |   News   |   Health Library   |   Consumer Guides   |   Organizations   |   En Español   |   Kids   |   Contact Us

Home > News

Drug Treatment for Osteoporosis Patients Urged

Bisphosphonates can be first-line therapy, particularly for those with hip fracture risk, physicians' group says in new guidelines.

  • E-mail this article
  • Subscribe to news
  • Printer friendly version
  • (SOURCE: American College of Physicians, news release, Sept. 15, 2008)

    MONDAY, Sept. 15 (HealthDay News) -- Physicians should offer drug treatment to women and men who've been diagnosed with osteoporosis or low bone density, says a recently issued clinical practice guideline by the American College of Physicians (ACP).

    In addition, doctors should consider drug treatment to prevent fractures in patients at risk of developing osteoporosis.

    The guideline authors didn't find evidence that one drug is definitively better than another and recommended that doctors make individual treatment decisions based on the risks, benefits, and a side effects profile of available drugs.

    However, the authors noted that bisphosphonates are reasonable options for beginning treatment, because these drugs reduce the risk of vertebral, non-vertebral and hip fractures.

    "Because treatment options may affect various parts of skeletal system differently, we analyzed the available evidence on numerous drugs to prevent fractures in men and women," guideline co-author Dr. Vincenza Snow, director of clinical programs and quality of care at ACP, said in a news release.

    "Bisphosphonates can be considered a first-line therapy, particularly for patients at risk for hip fracture. However, there is no clear evidence showing the appropriate duration of treatment with these drugs," Snow said.

    Upset stomach is a common side effect of bisphosphonates, and breakdown of the jaw bone is a rare and more serious risk associated with the drugs.

    Among other treatment options, estrogen reduces the risk of vertebral, non-vertebral and hip fractures but may increase the risk of certain cancers, stroke and blood clots, the guideline authors said. Drugs that work on estrogen receptors decrease spine fractures, but not hip fractures, and have no serious side effects.

    There's fair-to-good evidence that calcitonin and teriparatide reduce spine fractures, but calcitonin doesn't decrease the risk of other types of fractures. Neither drug has serious side effects.

    "The evidence on use of calcium, with or without vitamin D, is mixed, and the effectiveness is modest," Snow said.

    The new guideline is published in the Sept. 16 issue of Annals of Internal Medicine.

    More information

    The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more about medications to prevent and treat osteoporosis.

    Copyright © 2008 ScoutNews, LLC. All rights reserved.  External Links Disclaimer Logo

    HealthDayNews articles are derived from various sources and do not reflect federal policy. does not endorse opinions, products, or services that may appear in news stories. For more information on health topics in the news, visit the health library. logo USA dot Gov: The U.S. Government’s Official Web Portal
    footer shadow