| Staff Scientists and Clinicians
Joseph H. Callicott, M.D. |
|
|
Dr.
Callicott is Chief of the Unit
on Functional MRI within Clinical Brain Disorders Branch
of the Intramural Research Program, National Institute
of Mental Health, National Institutes of Health in Bethesda,
Maryland. He attended the College of William and Mary
and the University of Virginia School of Medicine and
completed psychiatry residency at the University of Virginia
and the NIMH. He is board certified in psychiatry. Dr.
Callicott is the recipient of a NARSAD Young Investigator
Award, the Society of Biological Psychiatry Lilly Fellowship
Award, and the APA Kempf Fund Award for Research Development
in Psychobiological Psychiatry. |
Research Interests |
Dr.
Callicotts research is focused on fMRI of working
memory in patients and controls. In particular, Dr. Callicott
has raised the issue of prefrontal cortical neuronal inefficiency
as a primary deficit in schizophrenia. fMRI data in healthy
subjects, patients, and their unaffected siblings is currently
used as an intermediate phenotype in clinical genetic
studies in the Clinical Brain Disorders Branch. |
Representative Selected Recent Publications: |
- Callicott JH, Bertolino
A, Mattay VS, Langheim FJ, Duyn J, Coppola R, Goldberg
TE, Weinberger DR: Physiological dysfunction
of the dorsolateral prefrontal cortex in schizophrenia:
revisited. Cereb Cortex, 10(11):1078-1092, 2000.
- Callicott JH, Bertolino
A, Egan MF, Mattay VS, Langheim FJ, Weinberger DR.: Selective relationship between prefrontal N-acetylaspartate
measures and negative symptoms in schizophrenia. Am
J Psychiatry, 157(10):1646-1651, 2000.
- Callicott JH, Egan MF,
Mattay VS, Bertolino A, Bone A, Verchinski BA, Weinberger
DR.: Physiological dysfunction of the dorsolateral
prefrontal cortex in cognitively intact siblings of
patients with schizophrenia. Am J Psych [in press].
- Egan MF, Goldberg TE,
Kolachana B, Callicott JH, Mazzanti CM, Straub R,
Goldman D, Weinberger DR:. Effect of COMT Val108/158Met
genotype on frontal lobe function and risk for schizophrenia.
Proc Natl Acad Sci USA, 98(12):6917-6922, 200`.
- Egan MF, Callicott JH*,
Kojima M*, Goldberg TE*, Kolachana BF, Bertolino A,
Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger
DR. The BDNF val66met polymorphism affects
activity-dependent secretion of BDNF and human memory
and hippocampal function. Cell [in press]. *(These
authors contributed equally).
|
Address:
|
Joseph H. Callicott, M.D. Chief, Unit on Cognition and Psychosis Program
10 Center Drive Room 4C-216, MSC 1364
Bethesda, MD 20892-1364 |
Phone: |
301-402-3081 |
Email Dr. Callicott |
Fax: |
301-451-5148 |
Lab Web Site: |
http://cbdb.nimh.nih.gov/ |
|
|
|
|
|