| | Principal Investigators
| Joel E. Kleinman, M.D., Ph.D. |
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|
Joel
E. Kleinman, M.D., Ph.D. is the Section Chief of the Section
on Neuropathology and the Deputy Chief of the Clinical
Brain Disorders Branch. Dr. Kleinman received his
B.S., M.D. and Ph.D. from the University of Chicago. He
completed an internship at San Francisco General Hospital
(University of California Medical School in San Francisco)
and residencies in psychiatry and neurology at Massachusetts
Mental Health Center (Harvard Medical School) and George
Washington University Medical School, respectively. He
has been at the NIMH since 1976. |
| Research Interests |
| The research program of the
Section on Neuropathology is primarily interested in the neuropathology of
schizophrenia and seeks to determine the molecular, cellular and genetic
mechanisms that underlie this syndrome. The section investigates these
mechanisms by focusing on neural circuits that are believed to underlie
schizophrenia, including the prefrontal cortex, medial temporal lobe, brainstem
and striatum with special influence on molecules involved in synapse formation,
plasticity and neurodevelopment. The section also investigates susceptibility
genes for schizophrenia and their relationships to these neural
circuits. |
| Representative Selected Recent Publications: |
- Holt DJ, Bachus SE, Hyde TM, Wittie M, Herman MM, Vangel M, Saper CB, Kleinman JE:
Reduced density of cholinergic interneurons in the ventral striatum in schizophrenia: an in situ hybridization study.
Biological Psychiatry. 58: 408-416, 2005.
- Egan MF, Straub RE, Goldberg TE, Yakub I, Callicott JH, Hariri AR, Mattay VS, Bertolino A, Hyde TM, Weickert CS, Akil M, Crook J, Vakkalanka RK, Balkissoon R, Gibbs RA, Kleinman JE, Weinberger DR:
Variation in GRM3 affects cognition, prefrontal glutamate, and risk for schizophrenia.
Proc Natl Acad Sci 101: 12604-12609, 2004. (View PDF)
- Weickert CS, Straub RE, McClintock BW, Matsumoto M, Hashimoto R, Hyde TM, Herman MM, Weinberger DR, Kleinman JE:
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain.
Archives of General Psychiatry 61: 544-555, 2004. (View PDF)
- Hashimoto R, Straub R, Weickert CS, Hyde TM, Kleinman JE, Weinberger DR:
Expression analysis of neuregulin-1 in the dorsolateral prefrontal cortex in schizophrenia.
Molecular Psychiatry 3: 299-307, 2004. (View PDF)
- Weickert CS, Hyde TM, Lipska BK, Herman MM, Weinberger DR, Kleinman JE:
Reduced brain-derived neurotrophic factor in prefrontal cortex of patients with schizophrenia.
Molecular Psychiatry 8:592-610, 2003. (View PDF)
- Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE:
Catechol-O-methyltransferase genotype and dopamine regulation in the human brain.
Journal of Neuroscience 23: 2008-2013, 2003. (View PDF)
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