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Brief Summary

GUIDELINE TITLE

The treatment of locally advanced pancreatic cancer.

BIBLIOGRAPHIC SOURCE(S)

  • Gastrointestinal Cancer Disease Site Group. Earle CC, Agboola O, Maroun J, Zuraw L. The treatment of locally advanced pancreatic cancer [full report]. Toronto (ON): Cancer Care Ontario (CCO); 2004 Feb 20 [online update]. 17 p. (Practice guideline report; no. 2-7). [29 references]

GUIDELINE STATUS

This is the current release of the guideline.

The FULL REPORT, initially the full original Guideline or Evidence Summary, over time will expand to contain new information emerging from their reviewing and updating activities.

Please visit the Cancer Care Ontario Web site for details on any new evidence that has emerged and implications to the guidelines.

BRIEF SUMMARY CONTENT

 RECOMMENDATIONS
 EVIDENCE SUPPORTING THE RECOMMENDATIONS
 IDENTIFYING INFORMATION AND AVAILABILITY
 DISCLAIMER

 Go to the Complete Summary

RECOMMENDATIONS

MAJOR RECOMMENDATIONS

The intent of treatment of locally advanced pancreatic cancer is palliation in symptomatic patients and prolongation of life in medically suitable cases. The following options are appropriate:

  • For medically suitable patients, current conventional practice is to offer combined chemotherapy and radiotherapy.
  • Outside a clinical trial, 5-fluorouracil (5-FU) given as bolus or infusion is the preferred chemotherapeutic agent to combine with radiotherapy. The optimal mode and duration of 5-fluorouracil delivery is unclear; however, infusional therapy appears to give better treatment outcome.

CLINICAL ALGORITHM(S)

None provided

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EVIDENCE SUPPORTING THE RECOMMENDATIONS

TYPE OF EVIDENCE SUPPORTING THE RECOMMENDATIONS

The recommendations are supported by evidence-based practice guidelines, meta-analyses, and randomized controlled trials.

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IDENTIFYING INFORMATION AND AVAILABILITY

BIBLIOGRAPHIC SOURCE(S)

  • Gastrointestinal Cancer Disease Site Group. Earle CC, Agboola O, Maroun J, Zuraw L. The treatment of locally advanced pancreatic cancer [full report]. Toronto (ON): Cancer Care Ontario (CCO); 2004 Feb 20 [online update]. 17 p. (Practice guideline report; no. 2-7). [29 references]

ADAPTATION

Not applicable: The guideline was not adapted from another source.

DATE RELEASED

2002 June 10 (revised 2004 Feb 20)

GUIDELINE DEVELOPER(S)

Program in Evidence-based Care - State/Local Government Agency [Non-U.S.]

GUIDELINE DEVELOPER COMMENT

The Practice Guidelines Initiative (PGI) is the main project of the Program in Evidence-based Care (PEBC), a Province of Ontario initiative sponsored by Cancer Care Ontario and the Ontario Ministry of Health and Long-Term Care.

SOURCE(S) OF FUNDING

Cancer Care Ontario
Ontario Ministry of Health and Long-Term Care

GUIDELINE COMMITTEE

Provincial Gastrointestinal Cancer Disease Site Group

COMPOSITION OF GROUP THAT AUTHORED THE GUIDELINE

For a current list of past and present members, please see the Cancer Care Ontario Web site.

FINANCIAL DISCLOSURES/CONFLICTS OF INTEREST

Members of the Gastrointestinal Cancer Disease Site Group disclosed potential conflict of interest information.

GUIDELINE STATUS

This is the current release of the guideline.

The FULL REPORT, initially the full original Guideline or Evidence Summary, over time will expand to contain new information emerging from their reviewing and updating activities.

Please visit the Cancer Care Ontario Web site for details on any new evidence that has emerged and implications to the guidelines.

GUIDELINE AVAILABILITY

Electronic copies: Available Portable Document Format (PDF) from the Cancer Care Ontario Web site.

AVAILABILITY OF COMPANION DOCUMENTS

The following is available:

PATIENT RESOURCES

None available

NGC STATUS

This summary was completed by ECRI on January 23, 2004. The information was verified by the guideline developer as of February 25, 2004. This NGC summary was updated by ECRI on September 24, 2004. The updated information was verified by the guideline developer on October 20, 2004.

COPYRIGHT STATEMENT

This NGC summary is based on the original guideline, which is subject to the guideline developer's copyright restrictions. Please refer to the Copyright and Disclaimer Statements posted at the Cancer Care Ontario Web site.

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DISCLAIMER

NGC DISCLAIMER

The National Guideline Clearinghouse™ (NGC) does not develop, produce, approve, or endorse the guidelines represented on this site.

All guidelines summarized by NGC and hosted on our site are produced under the auspices of medical specialty societies, relevant professional associations, public or private organizations, other government agencies, health care organizations or plans, and similar entities.

Guidelines represented on the NGC Web site are submitted by guideline developers, and are screened solely to determine that they meet the NGC Inclusion Criteria which may be found at http://www.guideline.gov/about/inclusion.aspx .

NGC, AHRQ, and its contractor ECRI Institute make no warranties concerning the content or clinical efficacy or effectiveness of the clinical practice guidelines and related materials represented on this site. Moreover, the views and opinions of developers or authors of guidelines represented on this site do not necessarily state or reflect those of NGC, AHRQ, or its contractor ECRI Institute, and inclusion or hosting of guidelines in NGC may not be used for advertising or commercial endorsement purposes.

Readers with questions regarding guideline content are directed to contact the guideline developer.
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