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Complete Summary

GUIDELINE TITLE

Anxiety disorders in patients with HIV/AIDS. Mental health care for people with HIV infection.

BIBLIOGRAPHIC SOURCE(S)

  • Anxiety disorders in patients with HIV/AIDS. In: Mental health care for people with HIV infection: HIV clinical guidelines for the primary care practitioner. New York (NY): New York State Department of Health; 2006 Mar. p. 1-8. [1 reference]

GUIDELINE STATUS

This is the current release of the guideline.

This guideline updates a previous version: Anxiety disorders in patients with HIV/AIDS. In: Mental health care for people with HIV infection: HIV clinical guidelines for the primary care practitioner. New York (NY): New York State Department of Health; 2001 Mar. p. 59-68.

** REGULATORY ALERT **

FDA WARNING/REGULATORY ALERT

Note from the National Guideline Clearinghouse: This guideline references a drug(s) for which important revised regulatory information has been released.

  • May 2, 2007, Antidepressant drugs: Update to the existing black box warning on the prescribing information on all antidepressant medications to include warnings about the increased risks of suicidal thinking and behavior in young adults ages 18 to 24 years old during the first one to two months of treatment.
  • March 14, 2007, Sedative-hypnotic drug products: Revisions to product labeling to include stronger language concerning potential risks including severe allergic reactions and complex sleep-related behaviors, such as sleep-driving.
  • October 25, 2006, Effexor (venlafaxine HCl): Published retrospective studies report that venlafaxine overdosage may be associated with an increased risk of fatal outcome.

COMPLETE SUMMARY CONTENT

 ** REGULATORY ALERT **
 SCOPE
 METHODOLOGY - including Rating Scheme and Cost Analysis
 RECOMMENDATIONS
 EVIDENCE SUPPORTING THE RECOMMENDATIONS
 BENEFITS/HARMS OF IMPLEMENTING THE GUIDELINE RECOMMENDATIONS
 CONTRAINDICATIONS
 IMPLEMENTATION OF THE GUIDELINE
 INSTITUTE OF MEDICINE (IOM) NATIONAL HEALTHCARE QUALITY REPORT CATEGORIES
 IDENTIFYING INFORMATION AND AVAILABILITY
 DISCLAIMER

SCOPE

DISEASE/CONDITION(S)

  • Human immunodeficiency virus infection/acquired immune deficiency syndrome (HIV/AIDS)
  • Anxiety disorders, including:
    • Panic attacks and disorder
    • Phobias
    • Generalized anxiety disorder
    • Obsessive-compulsive disorder
    • Acute stress disorder
    • Post-traumatic stress disorder
    • Adjustment disorder with anxious mood

GUIDELINE CATEGORY

Diagnosis
Management
Treatment

CLINICAL SPECIALTY

Allergy and Immunology
Family Practice
Infectious Diseases
Internal Medicine
Psychiatry
Psychology

INTENDED USERS

Advanced Practice Nurses
Health Care Providers
Physician Assistants
Physicians
Public Health Departments

GUIDELINE OBJECTIVE(S)

To provide guidelines for diagnosis and treatment of anxiety disorders in patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) in primary care settings

TARGET POPULATION

Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) in primary care settings with suspected anxiety disorder

INTERVENTIONS AND PRACTICES CONSIDERED

Diagnosis

  1. Consideration of signs and symptoms
  2. Distinguishing among anxiety disorders and excluding underlying medical conditions such as human immunodeficiency virus (HIV)-related central nervous system disease, endocrinopathies, cardiovascular and other conditions that may cause anxiety
  3. Reviewing patients' medication regimens and obtaining a thorough substance use history

Treatment/Management

  1. Referring patients who use substances or whose anxiety is persistent or severe and does not respond to standard treatment to mental health professionals
  2. Providing psychological support
  3. Medications, including benzodiazepines, selective serotonin re-uptake inhibitors (SSRIs), and tricyclic antidepressants

MAJOR OUTCOMES CONSIDERED

Not stated

METHODOLOGY

METHODS USED TO COLLECT/SELECT EVIDENCE

Hand-searches of Published Literature (Primary Sources)
Hand-searches of Published Literature (Secondary Sources)
Searches of Electronic Databases

DESCRIPTION OF METHODS USED TO COLLECT/SELECT THE EVIDENCE

Not stated

NUMBER OF SOURCE DOCUMENTS

Not stated

METHODS USED TO ASSESS THE QUALITY AND STRENGTH OF THE EVIDENCE

Expert Consensus (Committee)

RATING SCHEME FOR THE STRENGTH OF THE EVIDENCE

Not applicable

METHODS USED TO ANALYZE THE EVIDENCE

Review

DESCRIPTION OF THE METHODS USED TO ANALYZE THE EVIDENCE

Not stated

METHODS USED TO FORMULATE THE RECOMMENDATIONS

Expert Consensus

DESCRIPTION OF METHODS USED TO FORMULATE THE RECOMMENDATIONS

The Human Immunodeficiency Virus (HIV) Guidelines Program works directly with committees composed of HIV Specialists to develop clinical practice guidelines. These specialists represent different disciplines associated with HIV care, including infectious diseases, family medicine, obstetrics and gynecology, among others. Generally, committees meet in person 3 to 4 times per year, and otherwise conduct business through monthly conference calls.

Committees meet to determine priorities of content, review literature, and weigh evidence for a given topic. These discussions are followed by careful deliberation to craft recommendations that can guide HIV primary care practitioners in the delivery of HIV care. Decision making occurs by consensus. When sufficient evidence is unavailable to support a specific recommendation that addresses an important component of HIV care, the group relies on their collective best practice experience to develop the final statement. The text is then drafted by one member, reviewed and modified by the committee, edited by medical writers, and then submitted for peer review.

RATING SCHEME FOR THE STRENGTH OF THE RECOMMENDATIONS

Not applicable

COST ANALYSIS

A formal cost analysis was not performed and published cost analyses were not reviewed.

METHOD OF GUIDELINE VALIDATION

Peer Review

DESCRIPTION OF METHOD OF GUIDELINE VALIDATION

Not stated

RECOMMENDATIONS

MAJOR RECOMMENDATIONS

Key Point:

Patients with limited social support may be particularly susceptible to developing anxiety symptoms.

Clinical Presentation

Clinicians should consider the diagnosis of an anxiety disorder when a patient presents with common somatic symptoms, such as chest pain, diaphoresis, dizziness, gastrointestinal disturbances, and/or headache, for which no underlying medical etiology can be established.

Diagnosis

Differential Diagnosis

Other Mental Health Disorders and Medical Conditions

Clinicians should exclude other mental health disorders in patients who present with anxiety.

Clinicians should exclude medical conditions, including human immunodeficiency virus (HIV)-related central nervous system disease, in patients who present with anxiety.

Clinicians should review medication regimens and substance use history in patients with anxiety.

Refer to Table 1 in the original guideline document for medications that may cause anxiety-like symptoms in HIV patients.

Anxiety Disorders

See Figure 1 in the original guideline document for a structured approach to distinguishing among anxiety disorders.

Management of HIV-Infected Patient with Anxiety Disorders

Clinicians should refer patients with symptoms of anxiety to a psychiatrist for evaluation and possible ongoing treatment when:

  • Anxiety symptoms do not respond to standard pharmacologic treatment or basic supportive/behavioral interventions.
  • The diagnosis of an anxiety disorder is difficult to establish
  • Anxiety is persistent or severe.
  • Patients with obsessive-compulsive disorder have intrusive or disturbing thoughts or compulsive rituals that are poorly controlled with the current medication or that cause the patient marked subjective distress.
  • Anxiety occurs in patients with a significant substance use history or in those who are actively using substances.

Psychological/Supportive Intervention in the Primary Care Setting

Refer to the original guideline document for a discussion of specific supportive strategies.

Key Point:

Basic supportive and behavioral interventions are sufficient to alleviate anxiety in certain patients.

Pharmacologic Interventions in the Primary Care Setting

Clinicians should be familiar with the safety profiles of medications used to treat anxiety and how these medications may interact with those used in the treatment of HIV disease. (Refer to Table 1 in Appendix I of the companion document: Interactions Between HIV-Related Medications and Psychotropic Medications: Indications and Contraindications.)

General Principles in the Pharmacologic Treatment of Anxiety Disorders and Their Symptoms

No single medication will treat the spectrum of symptoms seen in patients with anxiety disorders. The following general principles will help determine the pharmacologic intervention that is most likely to be helpful (see Table, below).

Table. Commonly Used Psychotropic Medications in the Treatment of Anxiety Disorders and Anxiety Symptoms

Disorder or Symptom Medication or Medication Class
Panic disorder SSRIs
  • Citalopram
  • Escitalopram
  • Sertraline
  • Paroxetine
  • Fluoxetine
Tricyclics
  • Nortriptyline
  • Desipramine
  • Doxepin
  • Imipramine
Benzodiazepines
  • Lorazepam
  • Alprazolam
  • Clonazepam
Other
  • Venlafaxine
Generalized anxiety disorder Buspirone

SSRIs (listed above)
Obsessive-compulsive disorder SSRIs (listed above)

Other
  • Fluvoxamine
  • Clomipramine
  • Venlafaxine
Adjustment disorder with anxious mood Benzodiazepines (listed above)
Insomnia* Zolpidem

Benzodiazepines (listed above) and temazepam

Other
  • Trazodone
  • Doxepin
PTSD SSRIs (listed above)**
Major depression with significant anxiety*** SSRIs (listed above)

Benzodiazepines (listed above)

Other
  • Venlafaxine
  • Tricyclics (listed above)

*Nonpharmacologic approaches should be attempted before treatment with medication. See Chapter "Somatic Symptoms" in the original guideline document.

**Sertraline and paroxetine are the only U.S. Food and Drug Administration (FDA)-approved medications for PTSD. However, all SSRIs (in the same doses used for depression) are helpful in treating symptoms of depression and anxiety. See the New York State Department of Health AIDS Institute guideline Trauma and Post-Traumatic Stress Disorder in Patients with HIV/AIDS.

Treatment of Anxiety Disorders in Substance Users

Primary care clinicians should coordinate with a psychiatrist and/or addiction specialist when managing anxiety disorders among patients with substance use disorders. A psychiatric evaluation of these patients should be performed.

Clinicians should discuss the long-term risks of dependence, withdrawal, and abuse, as well as the intended course of treatment, with patients with substance use disorders or a history of substance use disorders before benzodiazepines or other controlled substances are used to treat an anxiety disorder.

Clinicians should make the decision to withhold benzodiazepines on a case-by-case basis, weighing the risks and benefits for patients with substance use disorders.

CLINICAL ALGORITHM(S)

An algorithm is provided in the original guideline document for "Distinguishing Anxiety Disorders."

EVIDENCE SUPPORTING THE RECOMMENDATIONS

TYPE OF EVIDENCE SUPPORTING THE RECOMMENDATIONS

The type of supporting evidence is not specifically stated for each recommendation.

BENEFITS/HARMS OF IMPLEMENTING THE GUIDELINE RECOMMENDATIONS

POTENTIAL BENEFITS

Appropriate diagnosis and management of anxiety disorders in patients with human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS)

POTENTIAL HARMS

  • Benzodiazepines should be used with caution because of the potential for dependence and abuse in some patients.
  • The use of tricyclic antidepressants is limited due to their side-effect profile and potential for drug-drug interactions.

Refer to Table 1 in Appendix I (see "Availability of Companion Documents" field) for interactions between HIV-related medications and psychotropic medications: indications and contraindications.

CONTRAINDICATIONS

CONTRAINDICATIONS

Refer to Table 1 in Appendix I (see "Availability of Companion Documents" field)  for a list of contraindicated drug combinations.

IMPLEMENTATION OF THE GUIDELINE

DESCRIPTION OF IMPLEMENTATION STRATEGY

Following the development and dissemination of guidelines, the next crucial steps are adoption and implementation. Once practitioners become familiar with the content of guidelines, they can then consider how to change the ways in which they take care of their patients. This may involve changing systems that are part of the office or clinic in which they practice. Changes may be implemented rapidly, especially when clear outcomes have been demonstrated to result from the new practice such as prescribing new medication regimens. In other cases, such as diagnostic screening, or oral health delivery, however, barriers emerge which prevent effective implementation. Strategies to promote implementation, such as through quality of care monitoring or dissemination of best practices, are listed and illustrated in the companion document to the original guideline (HIV clinical practice guidelines, New York State Department of Health; 2003), which portrays New York's HIV Guidelines Program. The general implementation strategy is outlined below.

  • Statement of purpose and goal to encourage adoption and implementation of guidelines into clinical practice by target audience.
  • Define target audience (providers, consumers, support service providers).
    • Are there groups within this audience that need to be identified and approached with different strategies (e.g., HIV Specialists, family practitioners, minority providers, professional groups, rural-based providers)?
  • Define implementation methods.
    • What are the best methods to reach these specific groups (e.g., performance measurement consumer materials, media, conferences)?
  • Determine appropriate implementation processes.
    • What steps need to be taken to make these activities happen?
    • What necessary processes are internal to the organization (e.g., coordination with colleagues, monitoring of activities)?
    • What necessary processes are external to the organization (e.g., meetings with external groups, conferences)?
    • Are there opinion leaders that can be identified from the target audience that can champion the topic and influence opinion?
  • Monitor progress.
    • What is the flow of activities associated with the implementation process and which can be tracked to monitor the process?
  • Evaluate.
    • Did the processes and strategies work?
    • Were the guidelines implemented?
    • What could be improved in future endeavors?

IMPLEMENTATION TOOLS

Clinical Algorithm
Personal Digital Assistant (PDA) Downloads
Resources

For information about availability, see the "Availability of Companion Documents" and "Patient Resources" fields below.

INSTITUTE OF MEDICINE (IOM) NATIONAL HEALTHCARE QUALITY REPORT CATEGORIES

IOM CARE NEED

Getting Better
Living with Illness

IOM DOMAIN

Effectiveness

IDENTIFYING INFORMATION AND AVAILABILITY

BIBLIOGRAPHIC SOURCE(S)

  • Anxiety disorders in patients with HIV/AIDS. In: Mental health care for people with HIV infection: HIV clinical guidelines for the primary care practitioner. New York (NY): New York State Department of Health; 2006 Mar. p. 1-8. [1 reference]

ADAPTATION

Not applicable: The guideline was not adapted from another source.

DATE RELEASED

2001 Mar (revised 2006 Mar)

GUIDELINE DEVELOPER(S)

New York State Department of Health - State/Local Government Agency [U.S.]

SOURCE(S) OF FUNDING

New York State Department of Health

GUIDELINE COMMITTEE

Mental Health Guidelines Committee

COMPOSITION OF GROUP THAT AUTHORED THE GUIDELINE

Committee Chair: Francine Cournos, MD, Professor of Clinical Psychiatry, Columbia University, New York State Psychiatric Institute - Unit 112, New York, NY

Committee Vice-Chair: Milton L Wainberg, MD, Associate Professor of Clinical Psychiatry, New York State Psychiatric Institute -- Unit 112, New York, NY

AIDS Institute Liaison: L. Jeannine Bookhardt-Murray, MD, Medical Director, Harlem United, New York, NY

AIDS Institute Representatives: Teresa C. Armon, RN, MS, Assistant Bureau Director of Community Support Services, New York State Department of Health, AIDS Institute, Albany, NY; Heather A Duell, LMSW, Director of Mental Health, Bureau of Community and Support Services, New York State Department of Health, AIDS Institute, Albany, NY

Committee Members: Bruce D Agins, MD, MPH, Assistant Professor of Medicine, Cornell University Medical College, New York, New York; Philip A Bialer, MD, Associate Professor of Clinical Psychiatry, Albert Einstein College of Medicine, Chief, Division of Consultation-Liaison Psychiatry, Beth Israel Medical Center, New York, NY; John M Budin, MD, Clinical Instructor in Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY; Mary Ann Cohen, MD, Director, AIDS Psychiatry, Associate Professor of Psychiatry, Mount Sinai Medical Center, New York, NY; Barbara A Conanan, RN, MS, SRO/Homeless Program Director, Saint Vincent's Catholic Medical Centers, Saint Vincent's Manhattan Department of Community Medicine, New York, NY; John AR Grimaldi, Jr, MD, Assistant Professor of Clinical Psychiatry, Sanford Weill-Cornell University Medical College, New York, NY, Chief Psychiatrist, David Rodgers Unit, Center for Special Studies, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY; Yiu Kee (Warren) Ng, MD, Director, Special Needs Clinic, New York Presbyterian Hospital, Columbia University Medical Center, New York, NY; Francine Rainone, DO, Director of Community Palliative Care, Montefiore Medical Center, Department of Family Medicine, Bronx, NY

Liaison: James J Satriano, PhD, Director of HIV/AIDS Programs, New York State Office of Mental Health, New York, New York, Assistant Professor of Clinical Psychology, Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY

FINANCIAL DISCLOSURES/CONFLICTS OF INTEREST

Not stated

GUIDELINE STATUS

This is the current release of the guideline.

This guideline updates a previous version: Anxiety disorders in patients with HIV/AIDS. In: Mental health care for people with HIV infection: HIV clinical guidelines for the primary care practitioner. New York (NY): New York State Department of Health; 2001 Mar. p. 59-68.

GUIDELINE AVAILABILITY

Electronic copies: Available from the New York State Department of Health AIDS Institute Web site.

Print copies: Available from Office of the Medical Director, AIDS Institute, New York State Department of Health, 5 Penn Plaza, New York, NY 10001; Telephone: (212) 268-6108

AVAILABILITY OF COMPANION DOCUMENTS

The following are available:

Print copies: Available from Office of the Medical Director, AIDS Institute, New York State Department of Health, 5 Penn Plaza, New York, NY 10001; Telephone: (212) 268-6108

This guideline is available as a Personal Digital Assistant (PDA) download from the New York State Department of Health AIDS Institute Web site.

PATIENT RESOURCES

None available

NGC STATUS

This NGC summary was completed by ECRI on May 5, 2005. It was updated by ECRI on April 13, 2006. This summary was updated by ECRI on November 22, 2006, following the FDA advisory on Effexor (venlafaxine HCl). This summary was updated by ECRI Institute on April 30, 2007, following the FDA advisory on Sedative-hypnotic drug products. This summary was updated by ECRI Institute on November 9, 2007, following the U.S. Food and Drug Administration advisory on Antidepressant drugs.

COPYRIGHT STATEMENT

DISCLAIMER

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