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No. Title Date Link
1997
1 Validation and Regulatory Acceptance of Toxicological Test Methods: A Report of the ad hoc Interagency Coordinating Committee on the Validation of Alternative Methods (NIH 97-3981) 03-01-1997 Link
1999
1 The Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals/Compounds. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH 99-4494) 03-11-1999 Link
2 Corrositex(R): An In Vitro Test Method for Assessing Dermal Corrosivity Potential of Chemicals. The Results of an Independent Peer Review Evaluation Coordinated by ICCVAM and NICEATM (NIH 99-4495) 06-01-1999 Link
2000
1 Background Review Document: Frog Embryo Teratogenesis Assay -- Xenopus (FETAX) 03-10-2000 Link
2 ICCVAM Authorization Act of 2000 (Public Law 106-545) 12-19-2000 Link
2001
1 ICCVAM Immunotoxicity Working Group Recommended Protocol for the Murine Local Lymph Node Assay (LLNA): Testing of Chemicals for Contact Sensitizing (Allergic Contact Dermatitis) Potential 01-12-2001 Link
2 ICCVAM Procedures for Test Methods That Have Been Endorsed by ECVAM 04-23-2001 Link
3 Guidance Document on Using In Vitro Data to Estimate In Vivo Starting Doses for Acute Toxicity: Based on Recommendations from an International Workshop Organized by ICCVAM and NICEATM 08-01-2001 Link
4 Background Review Document - EPISKIN(TM), EpiDerm(TM)(EPI-200), and Rat Skin Transcutaneous Electrical Resistance (TER) - In Vitro Test Methods for Assessing the Dermal Corrosivity Potential of Chemicals 08-12-2001 Link
5 ICCVAM Test Method Recommendations on Acute Systemic Toxicity (Appendix I of Workshop Report, NIH Publication 01-4499) 08-12-2001 Link
6 Report of the International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Results of an International Workshop Organized by ICCVAM and NICEATM (NIH Publication 01-4499) 08-17-2001 Link
7 ICCVAM Recommended Reporting Template: NRU Test 08-28-2001 Link
8 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH 02-4501): Volume 1 11-12-2001 Link
9 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH 02-4501): Volume 2 11-12-2001 Link
10 The Revised Up-and-Down Procedure: A Test Method for Determining the Acute Oral Toxicity of Chemicals (NIH 02-4501) (Table of Contents in HTML) 11-30-2001 Link
11 Annual Progress Report of the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) 12-19-2001 Link
2002
1 ICCVAM Evaluation of EPISKIN(TM), EpiDerm(TM), and the Rat Skin Transcutaneous Electrical Resistance (TER) Assay: In Vitro Test Methods for Assessing Dermal Corrosivity Potential of Chemicals (NIH 02-4502) 07-22-2002 Link
2 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Binding Assays (NIH 03-4504) 09-01-2002 Link
3 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Binding Assays (NIH 03-4506) 09-01-2002 Link
4 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Androgen Receptor Transcriptional Activation Assays (NIH 03-4507) 09-01-2002 Link
5 Background Review Document - Current Status of Test Methods for Detecting Endocrine Disruptors: In Vitro Estrogen Receptor Transcriptional Activation Assays (NIH 03-4505) 09-01-2002 Link
6 Expert Panel Evaluation of the Validation Status of In Vitro Test Methods for Detecting Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays 09-01-2002 Link
2003
1 ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors: Estrogen Receptor and Androgen Receptor Binding and Transcriptional Activation Assays (NIH 03-4503) 05-01-2003 Link
2 ICCVAM Guidelines for the Nomination and Submission of New, Revised and Alternative Test Methods (NIH 03-4508) 09-01-2003 Link
3 ICCVAM Biennial Progress Report (NIH 04-4509) 12-19-2003 Link
2004
1 Interagency Coordinating Committee on the Validation of Alternative Methods: Mission, Vision and Strategic Priorities 02-11-2004 Link
2 ICCVAM Review of the In Vivo Rabbit Dermal Corrosivity Test 02-20-2004 Link
3 Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion (NIH 04-4510) 05-10-2004 Link
2005
1 NICEATM Draft Technical Summary: Reduction of the Number of Animals Required for Ocular Irritancy Testing: A Brief Review of the Literature 01-04-2005 Link
2 NICEATM Draft Report: Interim Analysis of the Estimated Potential Underclassification Rates of the Current Rabbit Test for Detecting Ocular Corrosives and Severe Irritants 01-06-2005 Link
3 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants 03-12-2005 Link
4 Addendum to the In Vitro Ocular Toxicity Draft Background Review Document - Correction to Addendum Table IV-8 08-17-2005 Link
5 Draft Report: Analysis of the Estimated Underclassification and Overclassification Likelihoods of the Current In Vivo Rabbit Eye Test for Hazard Classification 11-04-2005 Link
6 Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants - ADDENDUM 11-12-2005 Link
2006
1 Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH 06-4512: Volume 1 of 2) 03-12-2006 Link
2 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Rabbit Eye (IRE) Test Method (NIH 06-4514) 03-12-2006 Link
3 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Isolated Chicken Eye (ICE) Test Method (NIH 06-4513) 03-12-2006 Link
4 Background Review Document - Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Hen's Egg Test - Chrorioallantoic Membrane (Het-CAM) Test Method (NIH 06-4515) 03-12-2006 Link
5 Background Review Document: Current Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants: Bovine Corneal Opacity and Permeability (BCOP) Test Method (NIH 06-4512: Volume 2 of 2) 03-12-2006 Link
6 Peer Review Panel Report: The Use of In Vitro Basal Cytotoxicity Test Methods for Estimating Starting Doses for Acute Oral Systemic Toxicity Testing 06-01-2006 Link
7 Finalized Addendum to ICCVAM Evaluation of In Vitro Test Methods for Detecting Potential Endocrine Disruptors 09-28-2006 Link
8 NICEATM Pre-Screen Evaluation of the In Vitro Endocrine Disruptor Assay (Robotic MCF-7 Cell Proliferation Assay of Estrogenic Activity) 10-16-2006 Link
9 Biennial Progress Report - Interagency Coordinating Committee on the Validation of Alternative Methods (NIH 06-4516) 10-24-2006 Link
10 Background Review Document: In Vitro Cytotoxicity Test Methods for Estimating Acute Oral Systemic Toxicity (NIH 07-4518) 11-01-2006 Link
11 ICCVAM Test Method Evaluation Report: In Vitro Cytotoxicity Test for Estimating Starting Doses for Acute Oral Systemic Toxicity Tests (NIH 07-4519) 11-01-2006 Link
12 ICCVAM Test Method Evaluation Report - In Vitro Ocular Toxicity Test Methods for Identifying Severe Irritants and Corrosives (NIH 07-4517) 11-01-2006 Link
2007
1 NICEATM/ICCVAM Brochure 03-23-2007 Link
2 Independent Peer Review Panel Report: Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products 04-30-2007 Link
2008
1 The NICEATM-ICCVAM Five-Year Plan (2008-2012) 02-05-2008 Link
2 Report on the ICCVAM-NICEATM/ECVAM Scientific Workshop on Alternative Methods to Refine, Reduce or Replace the Mouse LD50 Assay for Botulinum Toxin Testing 03-28-2008 Link
3 ICCVAM Background Review Document: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products 05-01-2008 Link
4 ICCVAM Test Method Evaluation Report: Validation Status of Five In Vitro Test Methods Proposed for Assessing Potential Pyrogenicity of Pharmaceuticals and Other Products 05-01-2008 Link
5 Independent Scientific Peer Review Panel Report - Validation Status of New Versions and Applications of the Murine Local Lymph Node Assay: A Test Method for Assessing the Allergic Contact Dermatitis Potential of Chemicals and Products 05-20-2008 Link
6 Biennial Progress Report: Interagency Coordinating Committee on the Validation of Alternative Methods - 2006-2007 10-23-2008 Link

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