National Toxicology Program

Background Review Documents	Expert Panel Report	OECD Test Guideline Proposals
Overview	Presentations	Recommendations and Agency Responses
Recommendations for Future Studies	Test Method Evaluation Report

Expert Panel Report The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) convened an expert panel meeting on January 11-12, 2005 to consider four in vitro test methods for measuring eye irritancy. The test methods included: The Bovine Corneal Opacity and Permeability [BCOP] assay The Hen's Egg Test-Chorioallantoic Membrane [HET-CAM] assay The Isolated Chicken Eye [ICE] assay The Isolated Rabbit Eye [IRE] assay The NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) organized the 24-member international panel in collaboration with the ICCVAM and the European Centre for the Validation of Alternative Methods (ECVAM). The meeting was held in response to a request by the U.S. EPA for ICCVAM to evaluate the usefulness and limitations of in vitro ocular safety testing methods.The Panel's conclusions and recommendations are contained in the Expert Panel Report published in March 2005. The Panel reconvened for a teleconference in September 2005 to consider additional data and information. An Addendum to the Expert Panel Report, covering discussions at the September 2005 teleconference, was published in November 2005

• Expert Panel Report: Evaluation of the Current Validation Status of In Vitro Test Methods for Identifying Ocular Corrosives and Severe Irritants (March 2005)
  
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• Addendum to the March 2005 Expert Panel Report, November 2005



• Ocular Expert Meeting (January 11-12, 2005) Presentations

  NOTE: The final expert panel presentations linked to this page represent some of the conclusions and recommendations of the panel but do not capture the entirety of their discussions and deliberations at the January 2005 meeting. A comprehensive account of the conclusions and recommendations of this panel is in their final report. These presentations are being made available for information purposes only and should not be be cited or quoted as the final recommendations of the panel.

• Supplemental Information for the January 2005 Expert Panel Meeting:


• NICEATM Draft Report: "Interim Analysis of the Estimated Potential Underclassification Rates of the Current Rabbit Test for Detecting Ocular Corrosives and Severe Irritants" (Jan. 6, 2005)


• NICEATM Draft Technical Summary: "Reduction of the Number of Animals Required for Ocular Irritancy Testing: A Brief Review of the Literature"



• Ocular Expert Panel Teleconference (September 19, 2005) Materials

Background and Additional Information

• Draft Report: Analysis of the Estimated Underclassification and Overclassification Likelihoods of the Current In Vivo Rabbit Eye Test for Hazard Classification (Nov. 4, 2005)