Overview and Performance Standards
ICCVAM evaluated and recommended four validated test methods for
assessing the dermal corrosivity hazard potential of chemicals:
Corrositex®, EPISKIN™, EpiDerm™ (EPI-200), and the rat skin
transcutaneous electrical resistance (TER) assay. At the request of the
U.S. EPA, ICCVAM established performance standards for the three
proprietary dermal corrosivity test methods (Corrositex®, EPISKIN™,
EpiDerm™ [EPI-200]) and the nonproprietary rat skin TER test method.
Recommended Performance Standards for In Vitro Test Methods for Skin Corrosion
(NIH Publication 04-4510, May 2004)
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ICCVAM Dermal Corrosivity and Irritation Working Group (DCIWG)
Proposed Minimum Performance Standards (MPS)
for three types of In Vitro Tests for Skin Corrosion (June 2003):
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