Overview and Recommendations
A peer review panel meeting to evaluate the validation status of a
revised Up-and-Down Procedure (UDP) for acute oral toxicity was held in July
2000, and was followed by a teleconference in August 2001. The Panel endorsed revisions to further reduce the number of
animals needed to estimate a median lethal dose (LD50) necessary for hazard
classification and labeling of chemicals and products. In agreement with the peer review panel, the ICCVAM
recommended that the revised UDP test guideline should: (1) replace the Organisation for Economic Cooperation
and Development (OECD) UDP test guideline from 1998 and (2)
be used instead of the conventional LD50 test to determine the acute oral toxicity hazard of chemicals. ICCVAM
concluded that use of the revised UDP test guideline will reduce and refine animal use.
Results of the
peer review were used to prepare a revised OECD Test Guideline and
Guidance Document on Acute Toxicity that was adopted in December
2001. ICCVAM's recommendations to use the revised UDP in place
of the conventional LD50 test were transmitted to Federal
agencies on March 21, 2003. Agency responses were made available to the
public on March 10, 2004.
ICCVAM Test Method Recommendations on Acute Oral Toxicity
- ICCVAM Test Method Recommendations:
Appendix A of Peer Review Evaluation Report
Agency Responses
- Transmittal Letter on Acute Systemic Toxicity
from Dr. Kenneth Olden to the Agency Heads
- Agency Responses:
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