National Toxicology Program

Background Materials for Workshop Participants

Relevant Federal Register Notices:

• "Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity; Request for Data and Suggested Expert Scientists" (Vol. 65, No. 115, pp. 37400-03; June 14, 2000)
• "Notice of an International Workshop on In Vitro Methods for Assessing Acute Systemic Toxicity: Workshop Agenda and Registration Information" (Vol. 65, No. 184, pp. 57203-05; Sept. 21, 2000)

List of Invited Experts, ICCVAM Agency Participants, and Organizing Committee

BACKGROUND MATERIALS

• BACKGROUND DOCUMENT


• APPENDICES


Appendix 1.

Part 1: OECD Harmonized Integrated Hazard Classification System for Human Health and Environmental Effects of Chemical Substances, as endorsed by the 28th Joint Meeting of the Chemicals Committee and the Working Party on Chemicals in November 1998. [View August 2001 version in PDF]

Part 2: Health Effects Test Guidelines, OPPTS 870.1100 Acute Oral Toxicity, EPA 712-C-98-190, August 1998 [PDF]
An updated version of this document (December 2002) can be found through the Agency Guidelines and Regulations Search Page

Appendix 2.

OECD Test Guideline 401: Acute Oral Toxicity.
This document can be ordered electronically at OECD Publications and Documents

Appendix 3.

Draft OECD Test Guideline 420: Acute Oral Toxicity - Fixed Dose Procedure.
This document is available in PDF Format at OECD Publications and Documents.

Appendix 4.

Draft OECD Test Guideline 423: Acute Oral Toxicity - Acute Toxic Class Method.
This document is available in Word or PDF Format at OECD Publications and Documents.

Appendix 5.

Draft OECD Test Guideline 425: Acute Oral Toxicity - Up-And-Down Procedure.
This document is available in PDF Format at OECD Publications and Documents.

Appendix 6.

The Multicenter Evaluation of In Vitro Cytotoxicity (MEIC) Summary, prepared by the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods, September 2000.

Appendix 7.

Assessment by ZEBET of the Correlation between In Vitro Cytotoxicity Data and Acute Oral Toxicity.
Part 1: Prediction of Human Lethal Concentrations by Cytotoxicity Data from 50 MEIC Chemicals
Part 2: Regression between Cytotoxicity and Acute Oral Toxicity
Part 3: Excel Spreadsheet for the Calculation of the Regression between Cytotoxicity and Acute Oral Toxicity.

Appendix 8.

Regulations and List of U.S. Department of Transportation DIVISION 6.1 MATERIALS
(These Codes of Federal Regulations can be retrieved at http://www.access.gpo.gov/nara/cfr/cfr-retrieve.html#page1)
Part 1: Definition of Class 6, Division 6.1 Materials (49 CFR 173.132).
Part 2: Assignment of Packing Group Designations For Division 6.1 Materials (49 CFR 173.133).
Part 3: Materials Assigned as Division 6.1 Materials (A Subset of the Hazardous Materials Table Provided in 49 CFR 172.101)

Appendix 9.

Summary List of Chemicals Evaluated in In Vitro Cytotoxicity Tests

• ADDITIONAL MATERIALS

Information pertaining to the 13th Meeting of the Scientific Group on Methodologies for the Safety Evaluation of Chemicals (SGOMSEC), published in Alternative Testing Methodologies (Environmental Health Perspectives, Volume 106, Supplement 2, April 1998).

Additional relevant publications suggested by Workshop participants.

Draft White Paper "The National Center for Toxicogenomics" - September 5, 2000.


• LIST OF REFERENCES