NIH Clinical Research Studies Listed By Institute of the Principal Investigator

National Institute of Neurological Disorders and Stroke (NINDS)

167 Protocols (130 Active Accrual of new subjects, 37 Follow-up of previously enrolled subjects)

Active Accrual, Protocols Recruiting New Patients 
* 08-N-0215:
Understanding the Anatomy and Physiology of the Sensory Experience and its Role in Generating Tics in Tourette Syndrome

* 08-N-0212:
Intermittent Theta-Burst Transcranial Magnetic Stimulation (TBS) for the Treatment of Parkinson Disease

* 08-N-0198:
Warfighter Head Injury Study - a Comprehensive, Multidisciplinary Research Evaluation

* 08-N-0192:
Functional Neuro-Imaging of Strategy use During Human Behavior

* 08-N-0189:
The Relationship Between Temporal Discrimination and Cortical Excitability in Humans

* 08-N-0181:
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia

* 08-N-0161:
Noninvasive Language Mapping in Patients with Localization-Related Epilepsy

* 08-N-0153:
The Role of Autoimmunity in Neurologic Complications of Celiac Disease

* 08-N-0134:
Pilot Study of Tolerability of Lithium Therapy in Patients with Spinocerebellar Ataxia Type I (SCA1)

* 08-N-0095:
Assessment of Cerebral Circulation and Perfusion in Adults after Neonatal Carotid Occlusion

* 08-N-0045:
Investigation of the Dopamine System in Frontotemporal Dementia

* 08-N-0044:
A Prospective Natural History Study of Patients with Neurofibromatosis Type 2 (NF2)

* 08-N-0040:
The Association Between Focal Dystonia (FD) and Complex Regional Pain Syndrome (CRPS)

* 08-N-0027:
HHV6B in Epilepsy Imaging and CSF Studies

* 08-N-0023:
Motor Cortex Reward Signaling in Parkinson Disease

* 08-N-0012:
L-Dihydroxyphenylserine (L-DOPS) for Norepinephrine Deficiency: Interactions with Carbidopa and Entacapone

* 07-N-0191:
Role of the Cortical Medial Frontal Areas in Blepharospasm

* 07-N-0190:
Neurobiological Studies of Psychogenic Movement Disorders and Non-Epileptic Seizures

* 07-N-0187:
Brain Connectivity and Sensorimotor Integration During Single/Dual Motor Tasks

* 07-N-0165:
Suppression and Facilitation of the Motor Cortex by Stimulation of the Cerebellum in Patients with Dystonia and Healthy Controls

* 07-N-0156:
Biomechanics of Human Epiglottal Movement and Inversion

* 07-N-0154:
Influence of Lesion Location on Cortical Reorganization after Chronic Stroke

* 07-N-0147:
Effect of Direct Current Brain Polarization on Verbal Memory

* 07-N-0137:
Expanding the Phenotype of the LRRK-2 Mutation in Individuals with History of Parkinson's Disease and their Relatives: a Prospective Study

* 07-N-0122:
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System

* 07-N-0103:
Imaging Serotoninergic Neurotransmission in Epilepsy

* 07-N-0092:
PET Evaluation of Brain Peripheral Benzodiazepine Receptors Using [(11)C]PBR28 in Patients with Multiple Sclerosis (MS)

* 07-N-0088:
The Characteristics of Sequence Effect in de novo and Advanced Parkinson's Disease

* 07-N-0072:
Neural Substrates of Lasting Motor Skill Learning by Spacing Effect

* 07-N-0066:
Direct Current Brain Polarization of Bilateral Prefrontal Cortex

* 07-N-0063:
Detecting a Reward Signal in the Motor Cortex

* 07-N-0050:
MRI of Alzheimer's Disease Imaging Amyloid Plaques in Persons With and Without Memory Problems

* 07-N-0022:
Enhancing Interhemispheric Disinhibition Between Motor Cortices Using Bilateral Brain Stimulation

* 07-N-0020:
Evaluation of the Plasticity of the Primary Motor Cortex and Motor Learning in Parkinson's Disease

* 07-N-0014:
The Use of Magnetic Resonance Imaging to Investigate Cortical Damage in Patients with Multiple Sclerosis and Correlation with Cognitive Dysfunction

* 06-N-0243:
Brain Connectivity Between Visual Input and Motor Output

* 06-N-0242:
The Effect of Surround Inhibition During Phasic Compared to Tonic Voluntary Finger Movement in Focal Hand Dystonia

* 06-N-0232:
Hypersensitivity in Tourette Syndrome: An Evaluation of Perceived Intensity Versus Threshold

* 06-N-0225:
Influencing Motor Performance in Patients with Stroke by Combined Theta Burst Stimulation and Carbidopa-Levodopa

* 06-N-0224:
Collection of Blood Samples for DNA Analysis in Motor Neuron Diseases

* 06-N-0212:
A Comparison of an Implanted Neuroprosthesis with Sensory Training for Improving Airway Protection in Chronic Dysphagia

* 06-N-0209:
Plasma Exchange for Autoimmune Autonomic Failure

* 06-N-0192:
Blepharospasm and the Experimental Modulation of Cortical Excitability in Primary and Secondary Motor Areas. A Pilot Study.

* 06-N-0187:
Anticonvulsive Effects of Transcranial DC Stimulation in Pharmacoresistant Focal Epilepsy

* 06-N-0174:
Cortical Function in Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis

* 06-N-0161:
Long-Term Motor Learning in Focal Hand Dystonia

* 06-N-0154:
An Exploratory Study on Detection of Cortical and White Matter Damage in Patients with Multiple Sclerosis Using Magnetic Resonance Imaging at 7 Tesla

* 06-N-0138:
Long-Term Improvement in Training Effects by Transcranial DC Stimulation

* 06-N-0128:
fMRI Studies of Task Specificity in Focal Hand Dystonia

* 06-N-0126:
Neurophysiology of Task-Specificity of Focal Hand Dystonia

* 06-N-0125:
Physiology of Weakness with Movement Disorders

* 06-N-0120:
Induction of Volitional Swallowing in Chronic Dysphagia Post Stroke: A Novel Mechanism-Based Intervention

* 06-N-0095:
Contribution of Interhemispheric Inhibition to Motor Learning

* 06-N-0085:
Two-Compartment Model of Diffusion Tensor Magnetic Resonance Imaging (DT-MRI) for the Diagnosis of Glioma Tumor Recurrence versus Radiation Necrosis

* 06-N-0084:
Brain Networks Responsible for Sense of Agency: An EEG Study

* 06-N-0080:
Implicit Tactile Learning in Chronic Stroke Enhanced by Non-Invasive Brain Stimulation of the Somatosensory Cortex

* 06-N-0048:
Changes in Activation Patterns in the Ventro-Medial Prefrontal Cortex of Healthy Adolescents During the Imagination and Observation of Aggressive Behavior

* 06-N-0047:
Reference Values for Plasma Catechols

* 06-N-0031:
Evaluation of Density and Pattern of Distribution of GABA A Receptors in the Brain of Patients with Focal Hand Dystonia Studied with PET using [11C] Flumazenil

* 06-N-0027:
Neuropsychiatric Correlates of Psychogenic Movement Disorder and Non-Epileptic Seizure

* 06-N-0023:
Brain Networks Responsible for Self-Agency: An fMRI study

* 06-N-0022:
PET Imaging of GABA Receptors in Succinic Semialdehyde Dehydrogenase Deficiency

* 06-N-0012:
Moving a Paralyzed Hand Through a Brain-Computer Interface Controlled by the Affected Hemisphere After Stroke

* 05-N-0228:
The Role of Cortical Coherence in Focal Hand Dystonia

* 05-N-0224:
Cortical Excitability in Succinic Semialdehyde Dehydrogenase Deficiency

* 05-N-0223:
Clinical Neurophysiology: Training and Normative Values

* 05-N-0189:
Neuropathological Basis of Spasmodic Dysphonia and Related Voice Disorders

* 05-N-0179:
MRI Measurement of Brain Metabolism Across the Sleep-Wake Cycle

* 05-N-0142:
Effects of Unilateral and Bilateral Training on Motor Function in Chronic Stroke

* 05-N-0122:
Placebo Controlled Study of the Therapeutic Effect of the Transcranial Electrical Polarization in Patients with Focal Hand Dystonia

* 05-N-0094:
Impaired Motor Learning and LTP/LTD-like Plasticity in Dystonia, are Associated with Abnormal Modulation of Cortical Excitability by Somatosensory Volleys

* 05-N-0075:
Evaluation of the Mechanism of NO Formation and Pharmacokinetics of Long-Term Intravenous Nitrite Infusion in Healthy Volunteers

* 05-N-0063:
NINDS Biomarkers in Multiple Sclerosis Study (BioMS)

* 05-N-0039:
An Exploratory Study on Detection of Cortical Damage in Patients with Multiple Sclerosis Using Magnetic Resonance Imaging

* 04-N-0264:
MR Rescue: MR and Recanalization of Stroke Clots using Embolectomy

* 04-N-0212:
Enhancement of Rehabilitative Treatment-Dependent Functional Recovery After Stroke by Transcranial Direct Current Stimulation (tDCS)

* 04-N-0210:
Towards the Establishment of Standards of Practice and the Initiation of Multi-Center, Multi-National Clinical Trials for Neonates and Children With Stroke

* 04-N-0159:
Functional MRI (fMRI) and Diffusion Tensor Imaging (DTI) in Temporal Lobe Epilepsy

* 04-N-0113:
Examining Associative Relations in Structured Event Complexes Using Functional Neuroimaging

* 04-N-0103:
Changes in Intracortical Inhibitory Processes are Associated With the Development of Implicit Learning of a Motor Task

* 04-N-0071:
Phase I/II Study of HTLV-I-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Using the Humanized MiK-beta-1 Monoclonal Antibody Directed Toward the IL-2/IL-15Rbeta Subunit (CD122) that Blocks IL-15 Action

* 04-N-0033:
MRI in Autosomal Dominant Partial Epilepsy with Auditory Features

* 03-N-0260:
Functional Brain Mapping of Laryngeal Sensorimotor Control in Voice Disorders

* 03-N-0224:
Remote Effects of Stroke on Cerebral Metabolism. Evaluation with Positron Emission Tomography and Proton Magnetic Resonance Spectroscopy

* 03-N-0220:
Safety Study of the Super Rapid Transcranial Magnetic Stimulation in Patients with Parkinson's Disease

* 03-N-0196:
Social Knowledge Representation in the Human Prefrontal Cortex

* 03-N-0171:
Combination Anti-platelet and Anti-coagulation Treatment After Lysis of Ischemic Stroke Trial (CATALIST)

* 03-N-0164:
Evaluation and Treatment of Neurosurgical Disorders

* 03-N-0142:
Development of 7 Tesla MRI Methodology for Anatomical Functional and Spectroscopic Imaging of the Brain

* 03-N-0134:
Neurophysiological Studies in Patients With Psychogenic Movement Disorders

* 03-N-0126:
Spatiotemporal Dynamics of Cortical Connectivity Involved in Tics and Voluntary Movements in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder: An EEG Study

* 03-N-0119:
The Effects of an NMDA-Receptor Antagonist in Idiopathic Voice Disorders

* 03-N-0116:
Transcranial Electrical Polarization for the Treatment of Bradykinesia and Rigidity in Patients with Parkinson's Disease

* 03-N-0004:
Clinical Laboratory Evaluation of Primary Chronic Autonomic Failure

* 02-N-0223:
fMRI Languages Studies In Young Children

* 02-N-0216:
Dopaminergic Modulation of Cerebral Connectivity during Sequential Finger Movements

* 02-N-0181:
Evaluation of Density and Pattern of Distribution of GABA A Receptors in Brain of Patients with Tourette's Syndrome Studied with PET using [11C] Flumazenil

* 02-N-0132:
In Vivo Mapping Of Structural and Biochemical Abnormalities In Patients With Primary Focal Dystonia

* 02-N-0128:
Evaluation of Tourette's Syndrome with Multimetabolite H-Magnetic Resonance Spectroscopy at 3T

* 02-N-0109:
Real-time Analysis of Scalp Electroencephalography and Magnetoencephalography During Production of Human Voluntary Movement

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