Protocol Number: 07-C-0028

Title:

Screening of Mannose-Binding Lectin (MBL) Status in Pediatric Hematology/Oncology Patients

Number:

07-C-0028

Summary:

Background:

Infections are a major cause of sickness and death in children with cancer.

Studies show that a protein called mannose-binding lectin (MBL) is important in immunity and that changes in blood levels of MBL are associated with serious infectious complications when the immune system is stressed.

A new genetically engineered MBL protein called rhMBL may be useful in treating some patients with low MBL levels.

Objectives:

To learn more about MBL in children with cancer.

To identify pediatric cancer patients with low MBL levels who may be eligible to participate in a future study of rhMBL therapy.

Eligibility:

Children with cancer between 2 and 17 years of age who were previously enrolled in an NIH study for cancer evaluation or treatment.

Design:

Blood samples will be obtained to study MBL in children with cancer.

Children found to have a low blood level of MBL may be offered enrollment in a treatment study using rhMBL.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Clinical hold/Recruitment or enrollment suspended

Gender: Male & Female

Referral Letter Required: Yes

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Infection

Immunogenicity

Innate Immunity

C4 Deposition

Host Defense

Recruitment Keyword(s):

Cancer

Infection

Hematological Disease

Pediatrics

Condition(s):

Mannose-Binding Lectin Deficiency

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Cancer Institute

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Anders EM, Hartley CA, Reading PC, Ezekowitz RA. Complement-dependent neutralization of influenza virus by a serum mannose-binding lectin. J Gen Virol. 1994 Mar;75 ( Pt 3):615-22.

Babula O, Danielsson I, Sjoberg I, Ledger WJ, Witkin SS. Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome. Am J Obstet Gynecol. 2004 Sep;191(3):762-6.

Babula O, Lazdane G, Kroica J, Ledger WJ, Witkin SS. Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women. Clin Infect Dis. 2003 Sep 1;37(5):733-7. Epub 2003 Aug 13.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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