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Protocol Number:
03-C-0228
- Title:
Characterization of Serum Proteomic Patterns in Neoplastic and Inflammatory Skin Disease
- Number:
03-C-0228
- Summary:
The purpose of this study is to determine whether computer-aided analysis of proteins found in the blood can distinguish between the serum protein patterns in healthy patients versus patients with selected skin diseases, either psoriasis or cutaneous T cell lymphoma. It is hoped that the information obtained in this study will be useful in the development of improved methods for the diagnosis, prognosis, and treatment of diseases such as psoriasis and cutaneous T-cell lymphoma.
Approximately 141 participants 18 years or older will be enrolled in this study, 47 for each of the study categories-healthy skin volunteers, patients with psoriasis, and patients with cutaneous T cell lymphoma. All participants will be examined by a dermatologist before being enrolled in the study. Each will fill out a questionnaire that details the participant's medical history and the general health of their skin. Investigators will then collect blood (20 cc) from each participant and analyze the serum for the presence of small proteins via a technique called mass spectroscopy.
Participants enrolled through the Clinical Center of the National Institutes of Health for the express purposes of this protocol will be compensated $50 for their involvement in this study.
- Sponsoring Institute:
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National Cancer Institute (NCI)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
-
CTCL
-
Mycosis Fungoides
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Psoriasis
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Inflammation
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Cancer
- Recruitment Keyword(s):
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Cutaneous T Cell Lymphoma
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CTCL
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Mycosis Fungoides
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Psoriasis
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Healthy Volunteer
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HV
- Condition(s):
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Psoriasis
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Cutaneous T-Cell Lymphoma
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Healthy
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
-
National Cancer Institute
- Contact(s):
-
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC, Liotta LA. Use of proteomic patterns in serum to identify ovarian cancer. Lancet. 2002 Feb 16;359(9306):572-7.
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Zackheim HS, Amin S, Kashani-Sabet M, McMillan A. Prognosis in cutaneous T-cell lymphoma by skin stage: long-term survival in 489 patients. J Am Acad Dermatol. 1999 Mar;40(3):418-25.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/16/2008
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