NIH Clinical Research Studies

Protocol Number: 03-C-0228

Active Followup, Protocols NOT Recruiting New Patients

Title:
Characterization of Serum Proteomic Patterns in Neoplastic and Inflammatory Skin Disease
Number:
03-C-0228
Summary:
The purpose of this study is to determine whether computer-aided analysis of proteins found in the blood can distinguish between the serum protein patterns in healthy patients versus patients with selected skin diseases, either psoriasis or cutaneous T cell lymphoma. It is hoped that the information obtained in this study will be useful in the development of improved methods for the diagnosis, prognosis, and treatment of diseases such as psoriasis and cutaneous T-cell lymphoma.

Approximately 141 participants 18 years or older will be enrolled in this study, 47 for each of the study categories-healthy skin volunteers, patients with psoriasis, and patients with cutaneous T cell lymphoma. All participants will be examined by a dermatologist before being enrolled in the study. Each will fill out a questionnaire that details the participant's medical history and the general health of their skin. Investigators will then collect blood (20 cc) from each participant and analyze the serum for the presence of small proteins via a technique called mass spectroscopy.

Participants enrolled through the Clinical Center of the National Institutes of Health for the express purposes of this protocol will be compensated $50 for their involvement in this study.

Sponsoring Institute:
National Cancer Institute (NCI)
Recruitment Detail
Type: Completed Study; data analyses ongoing
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
Special Instructions:
Currently Not Provided
Keyword(s):
CTCL
Mycosis Fungoides
Psoriasis
Inflammation
Cancer
Recruitment Keyword(s):
Cutaneous T Cell Lymphoma
CTCL
Mycosis Fungoides
Psoriasis
Healthy Volunteer
HV
Condition(s):
Psoriasis
Cutaneous T-Cell Lymphoma
Healthy
Investigational Drug(s):
None
Investigational Device(s):
None
Interventions:
None
Supporting Site:
National Cancer Institute

Contact(s):
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):
Petricoin EF, Ardekani AM, Hitt BA, Levine PJ, Fusaro VA, Steinberg SM, Mills GB, Simone C, Fishman DA, Kohn EC, Liotta LA. Use of proteomic patterns in serum to identify ovarian cancer. Lancet. 2002 Feb 16;359(9306):572-7.

Zackheim HS, Amin S, Kashani-Sabet M, McMillan A. Prognosis in cutaneous T-cell lymphoma by skin stage: long-term survival in 489 patients. J Am Acad Dermatol. 1999 Mar;40(3):418-25.

Active Followup, Protocols NOT Recruiting New Patients

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