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Protocol Number:
02-N-0221
- Title:
Stroke Genomics - A Correlative Study of Stroke Subtypes, Neuroimaging, Therapy and Outcome Measures
- Number:
02-N-0221
- Summary:
This study will characterize the gene response of the body's immune and inflammatory cells to stroke. There is a wide variation in stroke risk, stroke outcome, and response to clot-busting therapy for stroke. This variation may be due to differences in people's response to injury or infection, or to differences in genetic make-up between individuals. Genes store the biological information that determines the body's response to injury or infection. This study will analyze the activity of a large number of genes to try to learn which genes might be related to patient outcome. This, in turn, may lead to an understanding of which gene profiles are related to increased stroke risk and increased disability or death.
Healthy volunteers over age 21 and stroke patients over age 21 who are admitted to the NIH Stroke Program at Suburban Hospital in Bethesda, Md., may be eligible for this study. Volunteers will be screened with a medical history, blood pressure and pulse measurements, electrocardiogram, and neurological examination.
Participants will have 20 to 35 milliliters (about an ounce) of blood drawn for genetic studies. The genetic material will be extracted from the white blood cells and analyzed for normal and abnormal gene activity related to stroke.
- Sponsoring Institute:
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National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Completed Study; data analyses ongoing
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Special Instructions:
Currently Not Provided
- Keyword(s):
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Cerebrovascular Disease
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Gene Chip
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Inflammation
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Pathophysiology Stroke
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Stroke Genomics
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Stroke Subtypes
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Neuroimaging
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Clinical Outcome Measures
- Recruitment Keyword(s):
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Stroke
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Cerebrovascular Disease
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CVA
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Healthy Volunteer
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HV
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Normal Control
- Condition(s):
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Cerebrovascular Disease
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Stroke
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Interventions:
- None
- Supporting Site:
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National Institute of Neurological Disorders and Stroke
- Contact(s):
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This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
- Citation(s):
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Acierno JS Jr, A physical and transcript map of the MCOLN1gene region on human chromosome 19p13.3-p13.2. Genomics. 2001 Apr 15;73(2):203-10.
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Baird AE, Enlargement of human cerebral ischemic lesionvolumes measured by diffusion-weighted magnetic resonanceimaging. Ann Neurol. 1997 May;41(5):581-9.
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Baird AE, Magnetic resonance imaging of acute stroke. J CerebBlood Flow Metab. 1998 Jun;18(6):583-609. Review.
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/15/2008
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