NIH Clinical Research Studies

Protocol Number: 01-C-0236

Active Followup, Protocols NOT Recruiting New Patients

Title:
Follow-Up of a Phase-I Gene Therapy Trial of Patients with Leukocyte Adherence Deficiency
Number:
01-C-0236
Summary:
This study will provide long-term monitoring of two patients who received gene therapy for leukocyte adherence deficiency (LAD) under the Food and Drug Administration investigational new drug study BB-IND-7949. The IND protocol has been closed. No other patients are eligible for this study.

Patients previously enrolled in BB-IND-7949 (Retrovirus-Mediated Transfer of the cDNA for Human CD18 into Peripheral Blood Repopulating cells of Patients with Leukocyte Adherence Deficiency) will be followed at least yearly for an indefinite period of time to evaluate their medical status and look for treatment side effects. The follow-up visits at the NIH Clinical Center will involve the following:

- Interview regarding health status during the past year

- Blood draw of approximately 15 milliliters for 3 years, then 5 ml annually thereafter for studies related to LAD and to make sure no unexpected effects of gene therapy have occurred

The blood samples collected at the follow-up visits will be frozen and stored. If a serious medical problem arises, the sample may be checked for replication competent virus. If the gene therapy is suspected to be related to a medical problem, investigation may include a review of the patient's medical records or collection of additional blood or tissues for testing. If the patient should die, the family will be asked permission to perform an autopsy, regardless of the cause of death. Tissues taken at autopsy will be tested for any long-term effects from the gene therapy.

Sponsoring Institute:
National Cancer Institute (NCI)
Recruitment Detail
Type: No longer recruiting/follow-up only
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
Special Instructions:
Currently Not Provided
Keyword(s):
CD18
Retrovirus
RCR
Stem Cell
Gene Transfer
Recruitment Keyword(s):
Leukocyte Adhesion Deficiency
LAD
Condition(s):
Leukocyte Adhesion Deficiency Syndrome
Investigational Drug(s):
None
Investigational Device(s):
None
Interventions:
None
Supporting Site:
National Cancer Institute

Contact(s):
This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):
The severe and moderate phenotypes of heritable Mac-1, LFA-1 deficiency: their quantitative definition and relation to leukocyte dysfunction and clinical features

Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins

Active Followup, Protocols NOT Recruiting New Patients

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