Protocol Number: 98-C-0138

Title:

Evaluation of the Association of Polymorphisms in the Innate Immune System with the Risk for Blastomycosis Dermatitidis Infection in Patients not Infected with HIV and Complications Associated with Blastomycosis dermatitidis Infection

Number:

98-C-0138

Summary:

Innate immunity plays an important role for fungal recognition and initiation of fungicidal activity. We hypothesize that subtle differences in different molecules of innate immunity may contribute to either the predisposition or clinical course of infection with Blastomycosis dermatitidis. To test this hypothesis, we propose to analyze the allelic frequencies of 15 different genes (mannose binding lectin, Fc-gamma receptor IIa and IIb, Fc-gamma receptors IIIa and IIIb, myeloperoxidase, tumor necrosis factor-alpha and -beta, interleukin 1A and 1B, interleukin-1 receptor antagonist, interleukin-10, NRAMP-1, chitotriosidase, and chemokine receptor 5) and their intragenic polymorphic forms and to compare this data to the incidence and severity of Blastomycosis dermatitidis infection. With this study we hope to identify a group of molecules of innate immunity which influence the risk and severity of invasive Blastomycosis dermatitidis infection.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Completed Study; data analyses ongoing

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria: This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Special Instructions:

Currently Not Provided

Keyword(s):

Genetic

Variant Alleles

Risk Factor

Cancer

Transplantation

Recruitment Keyword(s):

None

Condition(s):

Blastomycosis

Investigational Drug(s):

None

Investigational Device(s):

None

Interventions:

None

Supporting Site:

National Cancer Institute

Contact(s):

This study is not currently recruiting new subjects. If you have questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.

Citation(s):

Variations in the NRAPM-1 gene and susceptibility to tuberculosis in West Africans

Interleukin-1 receptor antagonist gene polymorphism as a disease severity factor in systemic lupus erythematosis

Cloning of a cDNA encoding chitotriosdiase, a human chitinase produced by macrophages

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