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Protocol Number:
06-N-0242
- Title:
The Effect of Surround Inhibition During Phasic Compared to Tonic Voluntary Finger Movement in Focal Hand Dystonia
- Number:
06-N-0242
- Summary:
This study will examine and compare brain activity in people with focal hand dystonia (FHD) and healthy volunteers to obtain further knowledge about the underlying cause of FHD. Patients with dystonia have muscle spasms that cause abnormal postures while trying to perform a movement; FHD affects the hands and fine finger movements. During fine finger movement, the brain controls muscles in a process called surround inhibition. This process may be impaired in people with hand dystonia, leading to uncontrolled overactivity in muscles and impairing motor function.
Healthy volunteers and patients with FHD over 18 years of age may be eligible for this study. Candidates are screened with a physical and neurological examination.
In a series of three experiments conducted during a single clinic visit, participants undergo transcranial magnetic stimulation (TMS) while performing a finger movement. A wire coil is placed on the subject's scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that travels through the scalp and skull and causes small electrical currents in the outer part of the brain. The stimulation may cause muscle, hand or arm twitching, or may affect movement or reflexes. During the stimulation, the subject is asked to contract one finger.
In addition to TMS, subjects have surface electromyography. For this test, they sit in a chair with their hands placed on a pillow on their lap. The electrical activity of three muscles in the right hand is recorded by electrodes (small metal disks) taped to the skin over the muscles.
- Sponsoring Institute:
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National Institute of Neurological Disorders and Stroke (NINDS)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA:
PATIENTS:
18 years old or older
Presence of FHD
HEALTHY VOLUNTEERS:
18 years old or older
Right handedness
Absence of dystonia or other neurological disorder with any effect on the motor or sensory systems
EXCLUSION CRITERIA:
PATIENTS AND HEALTHY VOLUNTEERS:
Concurrent significant medical, surgical, neurological or psychiatric condition
Taking the following medications: antidepressants, anxiolytics, anticonvulsants, antipsychotics, antiparkinson, hypnotics, stimulants, and/or antihistamines
Presence of pacemaker, implanted medical pump, metal plate or metal object in skull or eye
History of seizure disorder
Patients- Received botulinum toxin injection within 3 months of starting the protocol
Subjects with known hearing loss
- Special Instructions:
Currently Not Provided
- Keywords:
-
Transcranial Magnetic Stimulation (TMS)
-
Writer's Cramp
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Electromyogram
- Recruitment Keyword(s):
-
Focal Hand Dystonia
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FHD
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Writer's Cramp
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Healthy Volunteer
-
HV
- Condition(s):
-
Focal Hand Dystonia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Neurological Disorders and Stroke
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Berardelli A, Rothwell JC, Hallett M, Thompson PD, Manfredi M, Marsden CD. The pathophysiology of primary dystonia. Brain. 1998 Jul;121 ( Pt 7):1195-212.
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Bressman SB. Dystonia genotypes, phenotypes, and classification. Adv Neurol. 2004;94:101-7.
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Defazio G, Aniello MS, Masi G, Lucchese V, De Candia D, Martino D. Frequency of familial aggregation in primary adult-onset cranial cervical dystonia. Neurol Sci. 2003 Oct;24(3):168-9.
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Bethesda, Maryland 20892. Last update: 09/16/2008
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