NIH Clinical Research Studies

Protocol Number: 06-N-0125

Active Accrual, Protocols Recruiting New Patients

Title:
Physiology of Weakness with Movement Disorders
Number:
06-N-0125
Summary:
This study will compare electroencephalograph (EEG) recordings in healthy volunteers and in people with movement disorders to examine brain activity associated with the weakness. EEG records the electrical activity of the brain ("brain waves").

Healthy volunteers and patients with arm or leg weakness who are between 18 and 80 years of age may be eligible for this study. Healthy subjects are screened with a medical history, physical and neurological examinations, and a questionnaire. They must be right-handed and never have had a neurological disease or head trauma.

All participants have an EEG. An elastic cap with electrodes is placed on the subject's scalp to record the brain's electrical activity. During the EEG, subjects are required to resist against a force with their arm, elbow, shoulder or leg for as long as they can. Several recordings are done with short breaks between them.

Sponsoring Institute:
National Institute of Neurological Disorders and Stroke (NINDS)
Recruitment Detail
Type: Participants currently recruited/enrolled
Gender: Male & Female
Referral Letter Required: No
Population Exclusion(s): Children

Eligibility Criteria:
INCLUSION CRITERIA:

-Both patients and healthy volunteers will be between age 18 and 80.

-Patients will be evaluated in the Human Motor Control Clinic at NINDS.

-The definite diagnosis of the disease may not be completely established at the time of recording.

-Patients have clear and reproducible symptoms of give way weakness of either upper or lower extremities.

-Patients have to be able to resist against the examiner for at least two seconds before giving way.

-Healthy volunteers are right handed adults without history of neurological disease or severe head trauma.

EXCLUSION CRITERIA:

-Subjects (patients or volunteers) who cannot understand the instructions and consent forms of the protocol will be excluded.

-Subjects who cannot follow the instruction during the entire recording for whatever reason will be excluded.

-Patients with a documented organic central nervous system lesion may be excluded from the study. This will be discussed in detail for each individual subject at the Human Motor Control Clinic.

Special Instructions:
Currently Not Provided
Keywords:
Movement-Related Potential
Electroencephalogram
Psychogenic Movement Disorders
Recruitment Keyword(s):
Psychogenic Movement Disorder
Healthy Volunteer
HV
Condition(s):
Movement Disorders
Investigational Drug(s):
None
Investigational Device(s):
None
Intervention(s):
None
Supporting Site:
National Institute of Neurological Disorders and Stroke

Contact(s):
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):
Terada K, Ikeda A, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary muscle relaxation. Electroencephalogr Clin Neurophysiol. 1995 Nov;95(5):335-45.

Terada K, Ikeda A, Yazawa S, Nagamine T, Shibasaki H. Movement-related cortical potentials associated with voluntary relaxation of foot muscles. Clin Neurophysiol. 1999 Mar;110(3):397-403.

Toma K, Honda M, Hanakawa T, Okada T, Fukuyama H, Ikeda A, Nishizawa S, Konishi J, Shibasaki H. Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study. J Neurosci. 1999 May 1;19(9):3527-34.

Active Accrual, Protocols Recruiting New Patients

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