INCLUSION CRITERIA:
Plus Tinnitus Plus Hearing loss subjects.
- Adults, between the ages of 30 to 65 years.
- Are able to hear and perceive sounds used in the experiment in the range 250 Hz to 2 KHz and have high-frequency sensorineural hearing loss beginning no lower than 2 KHz.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
- Experience tinnitus daily.
- Have had non-pulsatile tinnitus for at least 1 year.
- Have bilateral or bilateral with unilateral dominance tinnitus.
Minus Tinnitus Plus Hearing loss subjects.
- Adults, between the ages of 30 to 65 years.
- Are able to hear and perceive sounds used in the experiment in the range 250 Hz to 2 KHz and have high-frequency sensorineural hearing loss beginning no lower than 2 KHz.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
- Have never or rarely (i.e. transient episodes experienced by virtually everyone) experienced tinnitus.
Minus Tinnitus Minus Hearing loss subjects or normal volunteers.
- Adults, between the ages of 30 to 65 years.
- Have normal hearing.
- In good health and not currently taking certain medications regularly (e.g. antidepressants, antiseizure medications, antipsychotics, etc.).
EXCLUSION CRITERIA:
- Subjects who have pacemakers, aneurysm clips, metallic prostheses or shrapnel fragments.
- Subjects incapable of giving informed consent.
- Subjects with a positive pregnancy test.
- Children below the age of 18 years.
- Subjects with hyperacusis or misophonia (hyper-sensitivity to loud noises).
- Subjects with mood disturbances such as depression or anxiety.
- Subjects with a history of temporomandibular joint problems or who present symptoms of pain and tenderness of the temporomandibular joint on examination.
Subjects may be excluded for the following reasons that may cause difficulty with interpretation of the imaging data:
-Subjects with mental or physical illnesses, other than tinnitus that may cause problems with participation in the study.
-Subjects with current uncontrolled hypertension, or significant past history of cardiovascular disease and diabetes melitus.
-Subjects with a history of head trauma with loss of consciousness, epilepsy, seizures, a history of chemotherapy (neurotoxic or ototoxic) and other medical conditions that may alter cerebral functioning.
- Subjects who are taking or have a history of taking recreational drugs or alcoholism.
- Subjects with unilateral or asymmetrical hearing loss who have not had (or cannot provide documentation of) comprehensive neuro-otologic workup will be excluded.