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Protocol Number:
06-CH-0119
- Title:
Insulin Resistance and Breast Cancer: Implications for Preventive Counseling in Familial and Sporadic Cases
- Number:
06-CH-0119
- Summary:
This study will characterize risk factors associated with breast cancer development in some patients. In particular, it will examine the role of insulin in breast cancer in patients with and without a family history of the disease.
Women 30 to 70 years old who have been diagnosed with breast cancer and matched control healthy subjects with and without a family history of breast cancer may be eligible for this study.
Participants undergo the following procedures:
-Cancer-genetic counseling session, including family history, risk assessment, genetic testing for BRCA1 and BRCA2 (if criteria is met), interpretation of results and management options
-Medical history, including questions about symptoms or diseases, reproductive history, use of oral contraceptives, body weight, exercise, lifestyle, and demographic issues
-Drawing of family tree
-Examination of medical records
-Blood drawing for genetic and other tests
-CT scan of the abdomen (approximate time < 1 minute)
-Filling out questionnaires
- Sponsoring Institute:
-
National Institute of Child Health and Human Development (NICHD)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Female
- Referral Letter Required:
No
- Population Exclusion(s):
Male
Children
- Eligibility Criteria:
ELIGIBILITY CRITERIA:
Females (ages 30-70 years old) who have been diagnosed with breast cancer and age matched controls with and without a family history of breast cancer.
The actual selection of patients most appropriate for research and clinical training needs will be made by protocol investigators.
Referrals will be accepted from the patient recruitment office of the NIH, genetic counselors, geneticists, oncologists, and other health care providers in the area or anybody who reads the information about the study on the NIH world wide web site.
- Special Instructions:
Currently Not Provided
- Keywords:
-
Breast Cancer
-
Family History
-
Pre/Post Menopausal
-
Prevention
-
Risk-Factor
-
Body-Mass-Index
-
BRCA1
-
Insulin
-
Genetic Counseling
-
Penetrance
-
Risk Assessment
- Recruitment Keyword(s):
-
Breast Cancer
-
BRCA1
-
Family History
-
Risk Assessment
-
Healthy Volunteer
-
HV
- Condition(s):
-
Breast Cancer
-
Insulin Resistance
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Child Health and Human Development
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793
Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
-
Dumitrescu RG, Cotarla I. Understanding breast cancer risk -- where do we stand in 2005? J Cell Mol Med. 2005 Jan-Mar;9(1):208-21. Review.
-
Wolf I, Sadetzki S, Catane R, Karasik A, Kaufman B. Diabetes mellitus and breast cancer. Lancet Oncol. 2005 Feb;6(2):103-11. Review.
-
Milazzo G, Giorgino F, Damante G, Sung C, Stampfer MR, Vigneri R, Goldfine ID, Belfiore A. Insulin receptor expression and function in human breast cancer cell lines. Cancer Res. 1992 Jul 15;52(14):3924-30.
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