NIH Clinical Research Studies

Protocol Number: 04-CC-0119

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Title:
Biomarkers and Protein Mass Expression Profiles in Bronchoalveolar Lavage from Patients with Lung Infiltrates
Number:
04-CC-0119
Summary:
This study will examine the different types of proteins present in the lungs of patients with pneumonia to explore the causes of different types of the disease. Pneumonia is a condition that causes lung inflammation AND is often caused by an infection. It is usually diagnosed by lung x-rays and listening to the chest with a stethoscope. This method can diagnose pneumonia, but it does not provide information on the cause of the inflammation - information that might be helpful in guiding treatment. This study will measure proteins in the lungs of patients to see if certain proteins are associated with specific forms of pneumonia, and can thus serve as biomarkers for disease.

Patients undergoing diagnostic bronchoscopy at the NIH Clinical Center may participate in this study. Patients will undergo bronchoscopy and bronchoalveolar lavage as scheduled for their medical care. For this procedure, the patient's mouth and throat are numbed with lidocaine; a sedative may be given for comfort. A thin flexible tube called a bronchoscope is advanced through the nose or mouth into the lung airways to examine the airways carefully. Saline (salt water) is then injected through the bronchoscope into the air passage, acting as a rinse. A sample of fluid is then withdrawn for microscopic examination. Researchers in the current study will use some of the fluid obtained from the lavage to examine for protein content.

In addition to the bronchoscopy and bronchoalveolar lavage, participants will have about 2 tablespoons of blood drawn to compare blood test results with the results of the lung washings. Patients' medical records will be reviewed to obtain information on past medical history, current medical treatment, vital signs, and results of x-ray tests.

Sponsoring Institute:
National Institutes of Health Clinical Center (CC)
Recruitment Detail
Type: Participants currently recruited/enrolled
Gender: Male & Female
Referral Letter Required: Yes
Population Exclusion(s): None

Eligibility Criteria:
INCLUSION CRITERIA:

All eligible patients undergoing diagnostic bronchoscopy who provide consent for proteomic analysis of BAL fluid supernatant and chart review of patient characteristics will be included in this study.

and/or

All eligible patients undergoing diagnostic bronchoscopy who provide consent for oral washings and a 15 ml blood draw will be included in this study.

EXCLUSION CRITERIA:

Patients undergoing bronchoscopy but not wanting to participate with either the chart review or the proteomic analysis of BAL fluid supernatant will be excluded.

Special Instructions:
Currently Not Provided
Keywords:
Proteomics
Infection
Pneumonia
Mass Spectrometry
BAL
Recruitment Keyword(s):
Lung
Pulmonary Disease
Lung Infiltrates
Condition(s):
Pneumonia
Investigational Drug(s):
None
Investigational Device(s):
None
Intervention(s):
None
Supporting Site:
NIH Clinical Center

Contact(s):
Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):
Bartlett JG, Mundy LM. Community-acquired pneumonia. N Engl J Med. 1995 Dec 14;333(24):1618-24. Review. No abstract available. PMID: 7477199

Fine MJ, et al. A prediction rule to identify low-risk patients with community-acquired pneumonia. N Engl J Med. 1997 Jan 23;336(4):243-50. PMID: 8995086

Ranish JA, et al. The study of macromolecular complexes by quantitative proteomics. Nat Genet. 2003 Mar;33(3):349-55. Epub 2003 Feb 18. PMID: 12590263

Active Accrual, Protocols Recruiting New Patients

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