Protocol Number: 03-M-0211

Title:

Family Study of Affective and Anxiety Spectrum Disorders

Number:

03-M-0211

Summary:

This study will examine how depression, anxiety, and migraine run in families. It will help in defining the risk factors for physical, mental, and health problems-as well as define ways that those problems may be prevented and treated.

A broad range of ages among family members will be included to evaluate the patterns of how these disorders are expressed throughout people's lives. Children of all ages will be included, and those ages 8 to 17 will be interviewed directly.

Assessments will be collected through criteria of the Diagnostic and Statistical Manual of Mental Disorders IV as well as the spectrum, or range, of mood disorders and co-existing conditions. A member of the study team will visit the participants at home or will do an interview by telephone. Participation will take approximately 3 to 4 hours. Children will complete questionnaires given by the research team as well as questionnaires that they will do by themselves. The questions will pertain to the children's health, including physical and mental health and medical history, social relationships, problems, skills, and ways of dealing with important or stressful issues in their lives. These questionnaires will take up to 1 hour to complete.

Health history gathered from adult participants will pertain to height, weight, exercise, and general function. Women will be asked about the use of oral contraceptives, estrogen, and progesterone. In addition, there will be questionnaires on personality and temperamental traits, that is, behavior and impulsiveness. Questions will also involve social intuition, family and other environmental factors, general functioning, and basic demographics such as ethnicity, race, socioeconomic status, marital status, education level, and employment history.

Families enrolled in this phase of the research will be invited to participate in the next phase. There would be follow-up to evaluate the development of mood disorders, subtypes, and syndromes across the lifespan.

Sponsoring Institute:

National Institute of Mental Health (NIMH)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

GENERAL INCLUSION CRITERIA:

Probands will be included if they meet criteria for one of the disorders listed below. Controls will be excluded if they have one of the inclusion disorders. The probands will be required to be 18 years of age and English speaking.

BIPOLAR I INCLUSION CRITERIA:

Lifetime history of DSM-IV Bipolar I or Manic Episode.

BIPOLAR II INCLUSION CRITERIA:

Lifetime history of DSM-IV Bipolar II with duration of hypomania reduced to 2 or more days (according to RDC)

MAJOR DEPRESSION INCLUSION CRITERIA:

Lifetime history of at least 2 episodes of DSM-IV Major Depression

PANIC/GAD INCLUSION CRITERIA:

Lifetime history of DSM-IV diagnosis for Panic Disorder or GAD

PHOBIAS INCLUSION CRITERIA:

Lifetime history of DSM-IV diagnosis for social anxiety disorder, agoraphobia, or specific phobias (greater than or equal to 3)

MIGRAINE INCLUSION CRITERIA:

Lifetime history of IHS migraine with or without Aura

GENERAL EXCLUSION CRITERIA:

Few probands who consent to participate will be excluded if they meet the inclusion criteria. The only exclusion criteria include impaired ability to comprehend the interview or inability to read.

Special Instructions:

Currently Not Provided

Keywords:

Phenotypes

Comorbid Disorders

Migraine

Subtypes

Development

Genetic Epidemiology

Family Study

High Risk Study

Mood Disorders

Anxiety Disorders

Recruitment Keyword(s):

None

Condition(s):

Mood Disorders

Anxiety Disorders

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Mental Health

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s):

Kendell RE. Abstract Clinical validity. Psychol Med. 1989 Feb;19(1):45-55. Review.

Tsuang MT, Abstract Identification of the phenotype in psychiatric genetics. Eur Arch Psychiatry Clin Neurosci. 1993;243(3-4):131-42.

Smoller JW, Panic and phobic anxiety: defining phenotypes for genetic studies. Am J Psychiatry. 1998 Sep;155(9):1152-62.

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
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