Protocol Number: 02-C-0179

Title:

Collection of Blood from Patients with Cancer

Number:

02-C-0179

Summary:

This study will collect blood from patients with cancer to study the level of cells which decrease the immune response (suppressor cells) before and after chemotherapy. Patients 18 years of age and older with cancer may participate. This study does not involve treatment.

Participants will have about 50 ml (3 tablespoonfuls) of blood drawn. Depending on their condition, patients may be invited to enroll in a clinical research study involving chemotherapy, radiotherapy, or surgery. Additional 40-ml blood samples may be drawn during the course of treatment.

Sponsoring Institute:

National Cancer Institute (NCI)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): Children

Eligibility Criteria:

INCLUSION CRITERIA:

Patients 18 years of age and older are eligible.

Patients must have a performance status of ECOG 0,1, 2, or 3 for admission to this protocol.

Patients with malignancy are eligible.

EXCLUSION CRITERIA:

Children will not be eligible.

Special Instructions:

Currently Not Provided

Keywords:

Suppressor Cells

T Cells

CD4+/CD25+ Cells

Recruitment Keyword(s):

Cancer

Malignancy

Blood Sample

Condition(s):

Neoplasms

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Cancer Institute

Contact(s):

NCI Referral Office
National Institute of Health Clinical Center (CC), 9000 Rockville Pike, Bethesda, Maryland 20892, United States: NCI Clinical Trials Referral Office
Phone: 1-888-NCI-1937
Fax: Not Listed
Electronic Address: ncicssc@mail.nih.gov

Citation(s):

Shimizu J, Yamazaki S, Sakaguchi S Induction of tumor immunity by removing CD25+CD4+ T cells: a common basis between tumor immunity and autoimmunity J Immunol 1999 Nov 15;163(10):5211-8

Jonuleit H, Schmitt E, Stassen M, Tuettenberg A, Knop J, Enk AH Identification and functional characterization of human CD4(+)CD25(+) T cells with regulatory properties isolatedfrom peripheral blood J Exp Med 2001 Jun 4;193(11):1285-94

Levings MK, Sangregorio R, Roncarolo MG Related Articles Human cd25(+)cd4(+) t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitrowithout loss of functionJ Exp Med 2001 Jun 4;193(11):1295-302

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 09/16/2008