Protocol Number: 01-D-0184

Title:

Evaluation and Treatment of Bone and Mineral Disorders

Number:

01-D-0184

Summary:

This study has four objectives: 1) to provide investigators the opportunity to study bone specimens from patients with various skeletal diseases; 2) to treat patients with skeletal diseases at the NIH; 3) to expose NIH trainees to certain skeletal diseases; and 4) to gain more knowledge about skeletal diseases and stimulate further study of bone biology.

Anyone with a disease that affects the skeleton may be eligible for this study.

All evaluations, tests, procedures and treatments given study participants are used in the standard care of skeletal diseases. No experimental evaluations or treatments are offered. Patient evaluations include a medical history, review of medical records and routine physical examination. Based on the findings, other procedures may be recommended, including blood tests, urine tests, and imaging tests, such as X-rays, bone densitometry, bone scan, computed tomography (CT) and magnetic resonance imaging (MRI).

Bone specimens from participants will be collected for research use. Specimens will be obtained from bone removed during a patient's planned surgical procedure performed for medical care, or patients may be requested to have a bone biopsy-removal of a small piece of bone tissue-as part of the patient evaluation procedure.

Sponsoring Institute:

National Institute of Dental And Craniofacial Research (NIDCR)

Recruitment Detail

Type: Participants currently recruited/enrolled

Gender: Male & Female

Referral Letter Required: No

Population Exclusion(s): None

Eligibility Criteria:

INCLUSION CRITERIA:

Specimens to be shipped will be considered either "surgical waste" or the harvesting of the specimen will be approved by an IRB-approved protocol at the sending institution. The specimen will be sent with a copy of the signed consent.

Patients of any age, gender, or ethnicity who will help fulfill the objectives laid out in the protocol.

Women of childbearing age or lactating will have pregnancy ruled-out with a serum pregnancy test and/or not undergo testing involving radiation or receive medications without demonstrated safety in pregnancy.

Patients must be referred from a practitioner who will continue their care/evaluation upon discharge, or in tandem with this protocol.

EXCLUSION CRITERIA:

Patients with significant cognitive impairment and not able to give informed consent.

Patients with serious, uncontrolled metabolic organ system dysfunction (decompensated heart failure, diabetes, etc.).

Special Instructions:

Currently Not Provided

Keywords:

Bone

Dysplasia

Fragility

Osteomalacia

Recruitment Keyword(s):

Osteoporosis

Dysplasia

Osteomalacia

Bone Diseases

Skeletal Disease

Condition(s):

Bone Disease

Investigational Drug(s):

None

Investigational Device(s):

None

Intervention(s):

None

Supporting Site:

National Institute of Dental and Craniofacial Research

Contact(s):

Patient Recruitment and Public Liaison Office
Building 61
10 Cloister Court
Bethesda, Maryland 20892-4754
Toll Free: 1-800-411-1222
TTY: 301-594-9774 (local),1-866-411-1010 (toll free)
Fax: 301-480-9793

Electronic Mail:prpl@mail.cc.nih.gov

Citation(s): Not Provided

• Questions about participating in a study, please contact the Patient Recruitment and Public Liaison Office, CC.
• Technical questions regarding the Clinical Center web site, please contact the Department of Networks and Applications, CC.

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National Institutes of Health Clinical Center Bethesda, Maryland 20892. Last update: 09/16/2008