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Protocol Number:
99-M-0172
- Title:
Integrating EEG/MEG and fMRI: Activity Correlation Between Frontal and Temporal Lobe Structures in Schizophrenic Patients, Their Siblings and Unrelated Normal Volunteers
- Number:
99-M-0172
- Summary:
This study will explore how the brain works during memory testing in an effort to understand why some patients with schizophrenia have memory difficulties.
Patients with schizophrenia and their unaffected family members are eligible for this study. Studying family members may help identify the genes related to the memory deficit in schizophrenia. Normal volunteers will also be studied.
Normal volunteers, patients with schizophrenia, and their family members interested in participating in this study will be screened with a complete medical examination and psychiatric assessment, and performance of simple tasks. Study participants will be shown numbers on a screen and asked to recall them after a brief period. This will be done during electroencephalographic (EEG) recording, in which electrodes attached to the scalp measure the brain's electrical activity. The same test will be repeated while the patient has magnetic resonance imaging of the brain. The combined MRI and EEG testing will permit better localization of the brain's electrical activity.
- Sponsoring Institute:
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National Institute of Mental Health (NIMH)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
Controls as well as patients and siblings will be recruited from the ongoing sibling study (95-M-0150). Subjects who are considered to be eligible will be considered eligible for this protocol, too. In addition, all patients should be medication-free (greater than three days) or on single-medication (unchanged medication for greater than 2 weeks).
EXCLUSION CRITERIA:
Anticipated psychomotor non-compliance, which may affect the measurement quality, will also be a reason for prior (temporary) exclusion from the study.
- Special Instructions:
Currently Not Provided
- Keywords:
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Functional Connectivity
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Frontotemporal Interaction
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Electrophysiology
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Functional Magnetic Resonance Imaging
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Healthy Subjects
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Schizophrenia
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MEG
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Neuroimaging
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EEG
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MRI
- Recruitment Keyword(s):
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Schizophrenia
- Condition(s):
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Healthy
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Schizophrenia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Institute of Mental Health
- Contact(s):
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Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Relationship between electrical potentials of the hippocampus, amygdala and neocortex during instrumental conditioning reflexes
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Combined dynamics of EEG and evoked potentials I studies of simultaneously recorded EEG-EPograms in the auditory pathway, reticular formation and hippocampus of the cat brain during the walking stage
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P300-response: possible psychophysiological correlates in delta and theta frequency channels
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/15/2008
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