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Protocol Number:
92-EI-0113
- Title:
Immunopathology and Molecular Pathology of Ocular Diseases in Humans
- Number:
92-EI-0113
- Summary:
The purpose of this study is to better understand the processes involved in the development of various eye conditions, such as uveitis, disorders of the conjunctiva, cornea, vitreous and retina, metabolic or genetic eye diseases or eye tumors, in order to develop better methods of diagnosis and treatment.
Patients who require eye surgery to treat an eye disease or other disease in which the eye is involved may participate in this study. Samples of eye tissue and fluid that are normally removed and discarded during eye surgery will instead be given to researchers for study. The tissues will be examined under microscope and studied using sophisticated chemical and biological tests. Immune cells from blood samples may also be examined. These studies will help better understand and diagnose the various eye diseases and to develop more attractive therapies.
- Sponsoring Institute:
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National Eye Institute (NEI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
None
- Eligibility Criteria:
INCLUSION CRITERIA:
All specimens either male or female of any age with ocular disease that are collected at the NEI or its collaborating institutes, will be included in the study. Specimens would consist of material obtained from surgical specimens, biopsy specimens, and from post mortem materials. These would include but would not be limited to cases involving uveal, conjunctival, corneal, vitreo-retinal, orbital disorders, tumor, and metabolic abnormalities.
- Special Instructions:
Currently Not Provided
- Keywords:
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Ocular Pathology
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Ocular Immunology
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Clinicopathological Correlation
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Immunohistochemical Methods
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In Situ Hybridization
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Polymerase Chain Reaction
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Microdissection
- Recruitment Keyword(s):
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Ocular Disease
- Condition(s):
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Conjunctival Disease
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Corneal Disease
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Eye Disease
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Uveitis
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Vitreoretinopathy, Proliferative
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Eye Institute
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Association of interleukin-10 in the vitreous and cerebral spinal fluid and primary central nervous system lymphoma
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Apoptosis in posterior uveitis
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The immunopathology of uveitis
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National Institutes of Health Clinical Center
Bethesda, Maryland 20892. Last update: 09/17/2008
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