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Protocol Number:
86-H-0088
- Title:
Lymphocytapheresis of Patients with Pancytopenia
- Number:
86-H-0088
- Summary:
Aplastic anemia is a condition in which the cells normally found in blood are greatly decreased. The normal levels of white blood cells, red blood cells, and platelets are much lower in patients with aplastic anemia.
Because of these low levels of blood cells, patients with aplastic anemia have a variety of immune system abnormalities. However, low levels of blood cells make it difficult to collect specialized white blood cells (mononuclear cells) for research studies.
This study was designed to collect lymphocytes from patients with low levels of all blood cells (pancytopenia) for use in research. Patients participating in the study will undergo a special procedure known as lymphapheresis. During lymphapheresis blood is taken from the patient in a manner similar to blood donation. The white blood cells are selectively removed by spinning (centrifugation), and the remaining red blood cells and platelets are placed back (re-infused) into the donor's blood stream.
Patients participating in this study will not benefit directly from it. However, cells collected in this study may increase scientific knowledge and improve understanding and treatment for diseases like aplastic anemia.
- Sponsoring Institute:
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National Heart, Lung and Blood Institute (NHLBI)
- Recruitment Detail
- Type:
Participants currently recruited/enrolled
- Gender:
Male & Female
- Referral Letter Required:
No
- Population Exclusion(s):
Children
- Eligibility Criteria:
INCLUSION CRITERIA
All patients with aplastic anemia or other bone marrow failure in which we would not expect to obtain 1 X 10(8) mononuclear cells from 100 mls of peripheral blood (i.e. an absolute lymphocyte count approximately less than 2000 per mm(3)).
Age 18 or older.
EXCLUSION CRITERIA
Patients unable to comprehend the investigational nature of the procedure.
Patients unable to tolerate a temporary reduction of blood volume the equivalent of one unit of blood.
- Special Instructions:
Currently Not Provided
- Keywords:
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Bone Marrow Failure
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Lymphocytapheresis
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Pancytopenia
- Recruitment Keyword(s):
-
Aplastic Anemia
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Hematosuppressive Disease
- Condition(s):
-
Aplastic Anemia
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Pancytopenia
- Investigational Drug(s):
- None
- Investigational Device(s):
- None
- Intervention(s):
- None
- Supporting Site:
- National Heart, Lung and Blood Institute
- Contact(s):
-
Patient Recruitment and Public Liaison Office
Building 61 10 Cloister Court Bethesda, Maryland 20892-4754 Toll Free: 1-800-411-1222 TTY: 301-594-9774 (local),1-866-411-1010 (toll free) Fax: 301-480-9793 Electronic Mail:prpl@mail.cc.nih.gov
- Citation(s):
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Circulating activated suppressor T lymphocytes in aplastic anemia
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Interferon is a mediator of hematopoitic suppression in aplastic anemia in vitro and possibly in vivo
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Lymphokine abnormalities in aplastic anemia: implications for the mechanism of action of antithymocyte globulin
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Bethesda, Maryland 20892. Last update: 09/15/2008
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