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This Week in PNAS

Inner Workings

An over-the-shoulder look at scientists at work.

Core Concepts

A brief introduction to emerging topics in science.

Retrospective

Commentaries

PNAS Plus Significance Statements

Brief statements written by the authors about the significance of their papers.

Perspective

  • Evolutionary cell biology: Two origins, one objective

    • Michael Lynch,
    • Mark C. Field,
    • Holly V. Goodson,
    • Harmit S. Malik,
    • José B. Pereira-Leal,
    • David S. Roos,
    • Aaron P. Turkewitz,
    • and Shelley Sazer
    PNAS 2014 111 (48) 16990-16994; published ahead of print November 17, 2014, doi:10.1073/pnas.1415861111

Physical Sciences

Applied Physical Sciences

Chemistry

Earth, Atmospheric, and Planetary Sciences

Environmental Sciences

Physics

  • Revealing an unusual transparent phase of superhard iron tetraboride under high pressure

    • Komsilp Kotmool,
    • Thanayut Kaewmaraya,
    • Sudip Chakraborty,
    • Jonas Anversa,
    • Thiti Bovornratanaraks,
    • Wei Luo,
    • Huiyang Gou,
    • Paulo Cesar Piquini,
    • Tae Won Kang,
    • Ho-kwang Mao,
    • and Rajeev Ahuja
    PNAS 2014 111 (48) 17050-17053; published ahead of print November 17, 2014, doi:10.1073/pnas.1419244111

  • Force distribution affects vibrational properties in hard-sphere glasses

    • Eric DeGiuli,
    • Edan Lerner,
    • Carolina Brito,
    • and Matthieu Wyart
    PNAS 2014 111 (48) 17054-17059; published ahead of print November 18, 2014, doi:10.1073/pnas.1415298111

Social Sciences

Anthropology

Psychological and Cognitive Sciences

Social Sciences

Biological Sciences

Applied Biological Sciences

  • Aptamer photoregulation in vivo

    • Lele Li,
    • Rong Tong,
    • Hunghao Chu,
    • Weiping Wang,
    • Robert Langer,
    • and Daniel S. Kohane
    PNAS 2014 111 (48) 17099-17103; published ahead of print November 17, 2014, doi:10.1073/pnas.1420105111

  • NanoFlares for the detection, isolation, and culture of live tumor cells from human blood

    • Tiffany L. Halo,
    • Kaylin M. McMahon,
    • Nicholas L. Angeloni,
    • Yilin Xu,
    • Wei Wang,
    • Alyssa B. Chinen,
    • Dmitry Malin,
    • Elena Strekalova,
    • Vincent L. Cryns,
    • Chonghui Cheng,
    • Chad A. Mirkin,
    • and C. Shad Thaxton
    PNAS 2014 111 (48) 17104-17109; published ahead of print November 17, 2014, doi:10.1073/pnas.1418637111

  • An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein

    • Johan Seijsing,
    • Malin Lindborg,
    • Ingmarie Höidén-Guthenberg,
    • Heiko Bönisch,
    • Elin Guneriusson,
    • Fredrik Y. Frejd,
    • Lars Abrahmsén,
    • Caroline Ekblad,
    • John Löfblom,
    • Mathias Uhlén,
    • and Torbjörn Gräslund
    PNAS 2014 111 (48) 17110-17115; published ahead of print November 18, 2014, doi:10.1073/pnas.1417717111

Biochemistry

  • RecQ helicase and RecJ nuclease provide complementary functions to resect DNA for homologous recombination

    • Katsumi Morimatsu and
    • Stephen C. Kowalczykowski
    PNAS 2014 111 (48) E5133-E5142; published ahead of print November 19, 2014, doi:10.1073/pnas.1420009111

  • Combinatorial regulation of a signal-dependent activator by phosphorylation and acetylation

    • Jose C. Paz,
    • Sang-Ho Park,
    • Naomi Phillips,
    • Shigenobu Matsumura,
    • Wen-Wei Tsai,
    • Lawryn Kasper,
    • Paul K. Brindle,
    • Guangtao Zhang,
    • Ming-Ming Zhou,
    • Peter E. Wright,
    • and Marc Montminy
    PNAS 2014 111 (48) 17116-17121; published ahead of print November 17, 2014, doi:10.1073/pnas.1420389111

  • Goniometer-based femtosecond crystallography with X-ray free electron lasers

    • Aina E. Cohen,
    • S. Michael Soltis,
    • Ana González,
    • Laura Aguila,
    • Roberto Alonso-Mori,
    • Christopher O. Barnes,
    • Elizabeth L. Baxter,
    • Winnie Brehmer,
    • Aaron S. Brewster,
    • Axel T. Brunger,
    • Guillermo Calero,
    • Joseph F. Chang,
    • Matthieu Chollet,
    • Paul Ehrensberger,
    • Thomas L. Eriksson,
    • Yiping Feng,
    • Johan Hattne,
    • Britt Hedman,
    • Michael Hollenbeck,
    • James M. Holton,
    • Stephen Keable,
    • Brian K. Kobilka,
    • Elena G. Kovaleva,
    • Andrew C. Kruse,
    • Henrik T. Lemke,
    • Guowu Lin,
    • Artem Y. Lyubimov,
    • Aashish Manglik,
    • Irimpan I. Mathews,
    • Scott E. McPhillips,
    • Silke Nelson,
    • John W. Peters,
    • Nicholas K. Sauter,
    • Clyde A. Smith,
    • Jinhu Song,
    • Hilary P. Stevenson,
    • Yingssu Tsai,
    • Monarin Uervirojnangkoorn,
    • Vladimir Vinetsky,
    • Soichi Wakatsuki,
    • William I. Weis,
    • Oleg A. Zadvornyy,
    • Oliver B. Zeldin,
    • Diling Zhu,
    • and Keith O. Hodgson
    PNAS 2014 111 (48) 17122-17127; published ahead of print October 31, 2014, doi:10.1073/pnas.1418733111
    OPEN ACCESS ARTICLE
    See Commentary on page 16986 in issue 48 of volume 111

  • Structure of the meningococcal vaccine antigen NadA and epitope mapping of a bactericidal antibody

    • Enrico Malito,
    • Marco Biancucci,
    • Agnese Faleri,
    • Ilaria Ferlenghi,
    • Maria Scarselli,
    • Giulietta Maruggi,
    • Paola Lo Surdo,
    • Daniele Veggi,
    • Alessia Liguori,
    • Laura Santini,
    • Isabella Bertoldi,
    • Roberto Petracca,
    • Sara Marchi,
    • Giacomo Romagnoli,
    • Elena Cartocci,
    • Irene Vercellino,
    • Silvana Savino,
    • Glen Spraggon,
    • Nathalie Norais,
    • Mariagrazia Pizza,
    • Rino Rappuoli,
    • Vega Masignani,
    • and Matthew James Bottomley
    PNAS 2014 111 (48) 17128-17133; published ahead of print November 17, 2014, doi:10.1073/pnas.1419686111
    OPEN ACCESS ARTICLE

  • Structural model of an mRNA in complex with the bacterial chaperone Hfq

    • Yi Peng,
    • Joseph E. Curtis,
    • Xianyang Fang,
    • and Sarah A. Woodson
    PNAS 2014 111 (48) 17134-17139; published ahead of print November 17, 2014, doi:10.1073/pnas.1410114111

  • Protein−DNA binding in the absence of specific base-pair recognition

    • Ariel Afek,
    • Joshua L. Schipper,
    • John Horton,
    • Raluca Gordân,
    • and David B. Lukatsky
    PNAS 2014 111 (48) 17140-17145; published ahead of print October 13, 2014, doi:10.1073/pnas.1410569111
    OPEN ACCESS ARTICLE

  • Activity-regulating structural changes and autoantibody epitopes in transglutaminase 2 assessed by hydrogen/deuterium exchange

    • Rasmus Iversen,
    • Simon Mysling,
    • Kathrin Hnida,
    • Thomas J. D. Jørgensen,
    • and Ludvig M. Sollid
    PNAS 2014 111 (48) 17146-17151; published ahead of print November 17, 2014, doi:10.1073/pnas.1407457111
    OPEN ACCESS ARTICLE

  • Natural low-molecular mass organic compounds with oxidase activity as organocatalysts

    • Tatsuya Nishiyama,
    • Yoshiteru Hashimoto,
    • Hitoshi Kusakabe,
    • Takuto Kumano,
    • and Michihiko Kobayashi
    PNAS 2014 111 (48) 17152-17157; published ahead of print November 19, 2014, doi:10.1073/pnas.1417941111

Biophysics and Computational Biology

  • Relating influenza virus membrane fusion kinetics to stoichiometry of neutralizing antibodies at the single-particle level

    • Jason J. Otterstrom,
    • Boerries Brandenburg,
    • Martin H. Koldijk,
    • Jarek Juraszek,
    • Chan Tang,
    • Samaneh Mashaghi,
    • Ted Kwaks,
    • Jaap Goudsmit,
    • Ronald Vogels,
    • Robert H. E. Friesen,
    • and Antoine M. van Oijen
    PNAS 2014 111 (48) E5143-E5148; published ahead of print November 17, 2014, doi:10.1073/pnas.1411755111

  • Orientation of aromatic residues in amyloid cores: Structural insights into prion fiber diversity

    • Anna Reymer,
    • Kendra K. Frederick,
    • Sandra Rocha,
    • Tamás Beke-Somfai,
    • Catherine C. Kitts,
    • Susan Lindquist,
    • and Bengt Nordén
    PNAS 2014 111 (48) 17158-17163; published ahead of print November 17, 2014, doi:10.1073/pnas.1415663111

  • Fast high-resolution 3D total internal reflection fluorescence microscopy by incidence angle scanning and azimuthal averaging

    • Jérôme Boulanger,
    • Charles Gueudry,
    • Daniel Münch,
    • Bertrand Cinquin,
    • Perrine Paul-Gilloteaux,
    • Sabine Bardin,
    • Christophe Guérin,
    • Fabrice Senger,
    • Laurent Blanchoin,
    • and Jean Salamero
    PNAS 2014 111 (48) 17164-17169; published ahead of print November 17, 2014, doi:10.1073/pnas.1414106111

  • Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry

    • Albert Konijnenberg,
    • Duygu Yilmaz,
    • Helgi I. Ingólfsson,
    • Anna Dimitrova,
    • Siewert J. Marrink,
    • Zhuolun Li,
    • Catherine Vénien-Bryan,
    • Frank Sobott,
    • and Armağan Koçer
    PNAS 2014 111 (48) 17170-17175; published ahead of print November 17, 2014, doi:10.1073/pnas.1413118111

  • Fibroblasts probe substrate rigidity with filopodia extensions before occupying an area

    • Stephanie Wong,
    • Wei-Hui Guo,
    • and Yu-Li Wang
    PNAS 2014 111 (48) 17176-17181; published ahead of print November 17, 2014, doi:10.1073/pnas.1412285111

  • Structures of protective antibodies reveal sites of vulnerability on Ebola virus

    • Charles D. Murin,
    • Marnie L. Fusco,
    • Zachary A. Bornholdt,
    • Xiangguo Qiu,
    • Gene G. Olinger,
    • Larry Zeitlin,
    • Gary P. Kobinger,
    • Andrew B. Ward,
    • and Erica Ollmann Saphire
    PNAS 2014 111 (48) 17182-17187; published ahead of print November 17, 2014, doi:10.1073/pnas.1414164111

Cell Biology

  • Analysis of clock-regulated genes in Neurospora reveals widespread posttranscriptional control of metabolic potential

    • Jennifer M. Hurley,
    • Arko Dasgupta,
    • Jillian M. Emerson,
    • Xiaoying Zhou,
    • Carol S. Ringelberg,
    • Nicole Knabe,
    • Anna M. Lipzen,
    • Erika A. Lindquist,
    • Christopher G. Daum,
    • Kerrie W. Barry,
    • Igor V. Grigoriev,
    • Kristina M. Smith,
    • James E. Galagan,
    • Deborah Bell-Pedersen,
    • Michael Freitag,
    • Chao Cheng,
    • Jennifer J. Loros,
    • and Jay C. Dunlap
    PNAS 2014 111 (48) 16995-17002; published ahead of print October 31, 2014, doi:10.1073/pnas.1418963111

  • Inhibition of tumor cell proliferation and motility by fibroblasts is both contact and soluble factor dependent

    • Twana Alkasalias,
    • Emilie Flaberg,
    • Vladimir Kashuba,
    • Andrey Alexeyenko,
    • Tatiana Pavlova,
    • Andrii Savchenko,
    • Laszlo Szekely,
    • George Klein,
    • and Hayrettin Guven
    PNAS 2014 111 (48) 17188-17193; published ahead of print November 17, 2014, doi:10.1073/pnas.1419554111

Developmental Biology

Environmental Sciences

Evolution

Genetics

  • Simultaneous sequencing of oxidized methylcytosines produced by TET/JBP dioxygenases in Coprinopsis cinerea

    • Lukas Chavez,
    • Yun Huang,
    • Khai Luong,
    • Suneet Agarwal,
    • Lakshminarayan M. Iyer,
    • William A. Pastor,
    • Virginia K. Hench,
    • Sylvia A. Frazier-Bowers,
    • Evgenia Korol,
    • Shuo Liu,
    • Mamta Tahiliani,
    • Yinsheng Wang,
    • Tyson A. Clark,
    • Jonas Korlach,
    • Patricia J. Pukkila,
    • L. Aravind,
    • and Anjana Rao
    PNAS 2014 111 (48) E5149-E5158; published ahead of print November 18, 2014, doi:10.1073/pnas.1419513111

  • Synaptonemal complex extension from clustered telomeres mediates full-length chromosome pairing in Schmidtea mediterranea

    • Youbin Xiang,
    • Danny E. Miller,
    • Eric J. Ross,
    • Alejandro Sánchez Alvarado,
    • and R. Scott Hawley
    PNAS 2014 111 (48) E5159-E5168; published ahead of print November 17, 2014, doi:10.1073/pnas.1420287111
    OPEN ACCESS ARTICLE

  • Circular permutation of a synthetic eukaryotic chromosome with the telomerator

    • Leslie A. Mitchell and
    • Jef D. Boeke
    PNAS 2014 111 (48) 17003-17010; published ahead of print November 5, 2014, doi:10.1073/pnas.1414399111
    OPEN ACCESS ARTICLE

  • Comparison of the transcriptional landscapes between human and mouse tissues

    • Shin Lin,
    • Yiing Lin,
    • Joseph R. Nery,
    • Mark A. Urich,
    • Alessandra Breschi,
    • Carrie A. Davis,
    • Alexander Dobin,
    • Christopher Zaleski,
    • Michael A. Beer,
    • William C. Chapman,
    • Thomas R. Gingeras,
    • Joseph R. Ecker,
    • and Michael P. Snyder
    PNAS 2014 111 (48) 17224-17229; published ahead of print November 20, 2014, doi:10.1073/pnas.1413624111
    OPEN ACCESS ARTICLE

  • Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication

    • Michael J. Montague,
    • Gang Li,
    • Barbara Gandolfi,
    • Razib Khan,
    • Bronwen L. Aken,
    • Steven M. J. Searle,
    • Patrick Minx,
    • LaDeana W. Hillier,
    • Daniel C. Koboldt,
    • Brian W. Davis,
    • Carlos A. Driscoll,
    • Christina S. Barr,
    • Kevin Blackistone,
    • Javier Quilez,
    • Belen Lorente-Galdos,
    • Tomas Marques-Bonet,
    • Can Alkan,
    • Gregg W. C. Thomas,
    • Matthew W. Hahn,
    • Marilyn Menotti-Raymond,
    • Stephen J. O’Brien,
    • Richard K. Wilson,
    • Leslie A. Lyons,
    • William J. Murphy,
    • and Wesley C. Warren
    PNAS 2014 111 (48) 17230-17235; published ahead of print November 10, 2014, doi:10.1073/pnas.1410083111

  • High-throughput optical quantification of mechanosensory habituation reveals neurons encoding memory in Caenorhabditis elegans

    • Takuma Sugi,
    • Yasuko Ohtani,
    • Yuta Kumiya,
    • Ryuji Igarashi,
    • and Masahiro Shirakawa
    PNAS 2014 111 (48) 17236-17241; published ahead of print November 17, 2014, doi:10.1073/pnas.1414867111

Immunology and Inflammation

Medical Sciences

  • Tubulin hyperacetylation is adaptive in cardiac proteotoxicity by promoting autophagy

    • Patrick M. McLendon,
    • Bradley S. Ferguson,
    • Hanna Osinska,
    • Md. Shenuarin Bhuiyan,
    • Jeanne James,
    • Timothy A. McKinsey,
    • and Jeffrey Robbins
    PNAS 2014 111 (48) E5178-E5186; published ahead of print November 17, 2014, doi:10.1073/pnas.1415589111

  • Disruption of Lrp4 function by genetic deletion or pharmacological blockade increases bone mass and serum sclerostin levels

    • Ming-Kang Chang,
    • Ina Kramer,
    • Thomas Huber,
    • Bernd Kinzel,
    • Sabine Guth-Gundel,
    • Olivier Leupin,
    • and Michaela Kneissel
    PNAS 2014 111 (48) E5187-E5195; published ahead of print November 17, 2014, doi:10.1073/pnas.1413828111
    OPEN ACCESS ARTICLE

  • Agonists of growth hormone-releasing hormone stimulate self-renewal of cardiac stem cells and promote their survival

    • Victoria Florea,
    • Sonia S. Majid,
    • Rosemeire M. Kanashiro-Takeuchi,
    • Ren-Zhi Cai,
    • Norman L. Block,
    • Andrew V. Schally,
    • Joshua M. Hare,
    • and Claudia O. Rodrigues
    PNAS 2014 111 (48) 17260-17265; published ahead of print November 17, 2014, doi:10.1073/pnas.1420375111

  • Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy

    • Suping Zhang,
    • Bing Cui,
    • Hsien Lai,
    • Grace Liu,
    • Emanuela M. Ghia,
    • George F. Widhopf II,
    • Zhuhong Zhang,
    • Christina C. N. Wu,
    • Liguang Chen,
    • Rongrong Wu,
    • Richard Schwab,
    • Dennis A. Carson,
    • and Thomas J. Kipps
    PNAS 2014 111 (48) 17266-17271; published ahead of print November 19, 2014, doi:10.1073/pnas.1419599111
    OPEN ACCESS ARTICLE

  • VEGF-B selectively regenerates injured peripheral neurons and restores sensory and trophic functions

    • Victor H. Guaiquil,
    • Zan Pan,
    • Natalia Karagianni,
    • Shima Fukuoka,
    • Gemstonn Alegre,
    • and Mark I. Rosenblatt
    PNAS 2014 111 (48) 17272-17277; published ahead of print November 17, 2014, doi:10.1073/pnas.1407227111
    OPEN ACCESS ARTICLE

Microbiology

  • Complex two-component signaling regulates the general stress response in Alphaproteobacteria

    • Andreas Kaczmarczyk,
    • Ramon Hochstrasser,
    • Julia A. Vorholt,
    • and Anne Francez-Charlot
    PNAS 2014 111 (48) E5196-E5204; published ahead of print November 17, 2014, doi:10.1073/pnas.1410095111

  • Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein

    • Jianbo Chen,
    • David Grunwald,
    • Luca Sardo,
    • Andrea Galli,
    • Sergey Plisov,
    • Olga A. Nikolaitchik,
    • De Chen,
    • Stephen Lockett,
    • Daniel R. Larson,
    • Vinay K. Pathak,
    • and Wei-Shau Hu
    PNAS 2014 111 (48) E5205-E5213; published ahead of print November 17, 2014, doi:10.1073/pnas.1413169111

  • Densovirus associated with sea-star wasting disease and mass mortality

    • Ian Hewson,
    • Jason B. Button,
    • Brent M. Gudenkauf,
    • Benjamin Miner,
    • Alisa L. Newton,
    • Joseph K. Gaydos,
    • Janna Wynne,
    • Cathy L. Groves,
    • Gordon Hendler,
    • Michael Murray,
    • Steven Fradkin,
    • Mya Breitbart,
    • Elizabeth Fahsbender,
    • Kevin D. Lafferty,
    • A. Marm Kilpatrick,
    • C. Melissa Miner,
    • Peter Raimondi,
    • Lesanna Lahner,
    • Carolyn S. Friedman,
    • Stephen Daniels,
    • Martin Haulena,
    • Jeffrey Marliave,
    • Colleen A. Burge,
    • Morgan E. Eisenlord,
    • and C. Drew Harvell
    PNAS 2014 111 (48) 17278-17283; published ahead of print November 17, 2014, doi:10.1073/pnas.1416625111
    OPEN ACCESS ARTICLE

  • Global discovery of colonization determinants in the squid symbiont Vibrio fischeri

    • John F. Brooks II,
    • Mattias C. Gyllborg,
    • David C. Cronin,
    • Sarah J. Quillin,
    • Celeste A. Mallama,
    • Randi Foxall,
    • Cheryl Whistler,
    • Andrew L. Goodman,
    • and Mark J. Mandel
    PNAS 2014 111 (48) 17284-17289; published ahead of print November 17, 2014, doi:10.1073/pnas.1415957111
    OPEN ACCESS ARTICLE

Neuroscience

Physiology

  • Impact of circadian misalignment on energy metabolism during simulated nightshift work

    • Andrew W. McHill,
    • Edward L. Melanson,
    • Janine Higgins,
    • Elizabeth Connick,
    • Thomas M. Moehlman,
    • Ellen R. Stothard,
    • and Kenneth P. Wright Jr.
    PNAS 2014 111 (48) 17302-17307; published ahead of print November 17, 2014, doi:10.1073/pnas.1412021111

  • Syndecan 4 is required for endothelial alignment in flow and atheroprotective signaling

    • Nicolas Baeyens,
    • Mary Jo Mulligan-Kehoe,
    • Federico Corti,
    • David D. Simon,
    • Tyler D. Ross,
    • John M. Rhodes,
    • Thomas Z. Wang,
    • Cecile O. Mejean,
    • Michael Simons,
    • Jay Humphrey,
    • and Martin A. Schwartz
    PNAS 2014 111 (48) 17308-17313; published ahead of print November 17, 2014, doi:10.1073/pnas.1413725111

Psychological and Cognitive Sciences

Sustainability Science

Systems Biology

Corrections