Featured Articles
November 2014 |
Johan Halse, Susan Greenspan, Felicia Cosman, Graham Ellis, Arthur Santora, Albert Leung, Norman Heyden, Suvajit Samanta, Steven Doleckyj, Elizabeth Rosenberg and Andrew E. Denker
In postmenopausal women with low bone mass, treatment with MK-5442
resulted in transient pulses of PTH. Bone formation markers increased quickly and
bone resorption markers decreased temporarily, suggestive of an anabolic window.
However, there were no increases in BMD versus placebo.
Inhibin at 90: From Discovery to Clinical Application, a Historical Review
October 2014 |
Yogeshwar Makanji, Jie Zhu, Rama Mishra, Chris Holmquist, Winifred P. S. Wong, Neena B. Schwartz, Kelly E. Mayo and Teresa K. Woodruff
In this review, the authors provide a comprehensive summary of their current understanding of the biological role of inhibin, its relationship with
activin, its signaling mechanisms, and its potential value as a diagnostic marker for reproductive function and pregnancy-associated conditions.
Serotonin Regulates Calcium Homeostasis in Lactation by Epigenetic Activation of Hedgehog Signaling
November 2014 |
Jimena Laporta, Kimberly P. Keil, Samantha R. Weaver, Callyssa M. Cronick, Austin P. Prichard, Thomas D. Crenshaw, Galen W. Heyne, Chad M. Vezina, Robert J. Lipinski, and Laura L. Hernandez
These results support a new paradigm of 5-HT-mediated Shh regulation involving DNA methylation remodeling and promoter switching. In addition to having immediate implications for lactation biology, identification and characterization of a novel functional regulatory relationship between non-neuronal 5-HT, Hh signaling, and PTHrP offers new avenues for the study of these important factors in development and disease.
GPER-1 and Estrogen Receptor-β Ligands Modulate Aldosterone Synthesis
November 2014 |
Brasilina Caroccia, Teresa M. Seccia, Abril Gonzalez Campos, Francesca Gioco, Maniselvan Kuppusamy, Giulio Ceolotto, Eugenia Guerzoni, Francesca Simonato, Sara Mareso, Livia Lenzini, Ambrogio Fassina and Gian Paolo Rossi
These results support the conclusion that in humans 17 β-estradiol inhibits aldosterone synthesis by acting via ERβ. Pharmacologic disinhibition of ERβ unmasks a potent secretagogue effect of 17 β-estradiol that involves PKA signaling.
December 2014 |
Reema S. Wahdan-Alaswad, Dawn R. Cochrane, Nicole S. Spoelstra, Erin N. Howe, Susan M. Edgerton, Steven M. Anderson, Ann D. Thor and Jennifer K. Richer
The anti-diabetic drug metformin has been shown to selectively kill cancer stem cells, and triple-negative breast cancer (TNBC) cell lines are more sensitive to the effects of metformin as compared to luminal breast cancer. However, the mechanism underlying the enhanced susceptibility of TNBC to metformin has not been elucidated. These studies provide mechanistic insight into metformin-induced killing of TNBC.
